Cation Radical Explorations

阳离子自由基探索

• 批准号: 8918556
• 负责人: Joseph Dinnocenzo
• 金额: $ 23.85万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-02-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8918556&HistoricalAwards=false
• 关键词: Cation; Radical; Explorations

This grant from the Organic Dynamics Program supports the continuing work of Dr. Joseph P. Dinnocenzo at the University of Rochester, who is studying the reactions of molecules from which a single electron has been removed. Investigations of these reactive species will provide fundamental information on acid-base reactions and should lead to new methodology in synthetic organic chemistry. The experiments to be carried out by Dr. Dinnocenzo will comprise two related investigations of cation radicals. The first is designed to provide a detailed understanding of the kinetic acidities of tertiary amine cation radicals and alkylaromatic cation radicals. Preparation, characterization, and proton-transfer studies of isolable cation radical salts will afford kinetic and thermodynamic data that will help to identify the similarities and differences between cation radical deprotonations and those of neutral, closed-shell organic molecules. The second investigation is designed to elucidate the scope, mechanism, and synthetic applications of cation radical reactions for cyclopropanes having unsaturated substituents.

有机动力学计划的这项赠款支持罗切斯特大学的约瑟夫·D·迪诺科佐（Joseph P. Dinnocenzo）博士的持续工作，后者正在研究删除单个电子的分子的反应。 对这些反应性物种的研究将提供有关酸碱反应的基本信息，并应导致合成有机化学的新方法。 Dinnocenzo博士要进行的实验将包括两项相关的阳离子自由基研究。 第一个旨在详细理解三元胺阳离子自由基和烷基芳族阳离子自由基的动力学酸度。 可分离阳离子自由基盐的制备，表征和质子转移研究将提供动力学和热力学数据，这将有助于确定阳离子自由基质子化和中性，封闭壳有机分子的相似性和差异。 第二项研究旨在阐明阳离子自由基反应在具有不饱和取代基的环丙烷中的范围，机制和合成应用。