Radical Migration Reactions Driven by Sustainable Transition-Metal Catalysis

可持续过渡金属催化驱动的自由基迁移反应

• 批准号: 2400279
• 负责人: Ming-Yu Ngai
• 金额: $ 49.77万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2400279&HistoricalAwards=false
• 关键词: Radical; Migration; Reactions; Driven; Sustainable

With the support of the Chemical Catalysis program in the Division of Chemistry, Professor Ming-Yu Ngai of Purdue University will study first-row transition metals in catalysis to establish new chemical processes and foster sustainable practices. This project aims to harness the reactivity of earth-abundant cobalt and nickel catalysts to develop new methods to functionalize carbohydrates and other important small molecule building blocks. The project seeks to both further understanding of the fundamental reactivity and mechanisms in these processes as well as develop new reactions to facilitate access to molecular scaffolds with potential societal impacts. Through collaboration with the College of Science K-12 Outreach team at Purdue, the project also seeks to inspire high school students by introducing them to sustainable catalysis concepts, highlighting chemistry's role in solving global challenges and promoting sustainability. By contributing to the scientific understanding of complex radical migration-related mechanisms, these studies have the potential to catalyze the development of related sustainable methodologies in organic synthesis.Under this award, Professor Ngai and his research team will explore the integration of ground-state metalloradical properties of cobalt and nickel complexes with 1,2-radical migration (RaM) reactivity. The project is set to unveil novel pathways for the site- and stereoselective functionalization of carbohydrates—a significant challenge in carbohydrate chemistry—and to broaden the reaction scope of allyl carboxylates. Through a combination of experimental and computational studies, the team aims to develop a catalytic platform that provides for axial and equatorial selectivity of the C2-arylation reaction. These investigations are expected to provide new insights into radical migratory cross-coupling reactions mediated by nickel and cobalt catalysts, and in so doing contribute to advances in radical chemistry and sustainable catalytic processes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学催化计划中，普渡大学化学催化计划的支持下，普渡大学的明尤·恩吉（Ming-Yu ngai）将研究催化中的第一行过渡金属，以建立新的化学过程并促进可持续实践。该项目旨在利用土壤丰富的钴和镍催化剂的反应性开发新方法，以使碳水合物和其他重要的小分子构建块官能化。该项目旨在进一步了解这些过程中的基本反应性和机制，以及开发新的反应以促进具有潜在社会影响的分子支架。通过与普渡大学科学学院K-12外展团队的合作，该项目还旨在通过向他们介绍可持续的催化概念来激发高中生，从而强调化学在解决全球挑战和促进可持续性方面的作用。通过对复杂的激进移民相关机制的科学理解，这些研究有可能催化有机合成中相关的可持续方法的发展。在此奖项之元奖之后，Ngai教授及其研究团队将探索与1,2-Rad-Radical Cripation（Ram crimations）cobalt and Nickel Complexse（RAM迁移）的基础金属质量的整合。该项目将公布新的途径，以实现碳氢化物的位点和立体选择性功能化（碳氢化物化学方面的重大挑战），并扩大了所有羧酸盐的反应范围。通过实验和计算研究的结合，该团队旨在开发一个催化平台，从而提供了C2乳化反应的轴向和等效性选择性。预计这些研究将提供对由Nickel和Cobalt催化剂介导的激进迁移式交叉偶联反应的新见解，并因此有助于激进化学和可持续的催化过程的进步。该奖项反映了NSF的法规任务，并认为通过基金会的知识优点和广泛的crietia criperia criperia crighia crighia crighia the Issution被认为是宝贵的支持。