RUI: Acquisition of an FT-NMR Spectrometer

RUI：购买 FT-NMR 光谱仪

• 批准号: 8910768
• 负责人: Robin Kinnel
• 金额: $ 10.85万
• 依托单位: Hamilton College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8910768&HistoricalAwards=false
• 关键词: RUI; Acquisition; FT; NMR; Spectrometer

This is a proposal to obtain a 300 MHz nuclear magnetic resonance spectrometer equipped with variable temperature 1H/13C probe and a variable temperature controller. The instrument will serve as a major research tool by members of the chemistry department in the following areas: 1. isolation, structure proof and synthesis of biologically significant natural products. 2. NMR studies of calmodulin - peptide interactions 3. thermodynamic study of the hydrophobic interaction These research efforts require high sensitivity and resolution plus variable temperature control. Acquisition of this instrument is expected to have a dramatic, positive effect on the research efforts of the Department. The utilization of the instrument will involve 5-10 undergraduates a year in senior research and similar number in summer research.

本提案旨在获得配备可变温度 1H/13C 探头和可变温度控制器的 300 MHz 核磁共振波谱仪。 该仪器将作为化学系成员在以下领域的主要研究工具： 1. 具有生物学意义的天然产物的分离、结构证明和合成。 2. 钙调蛋白-肽相互作用的核磁共振研究 3. 疏水相互作用的热力学研究 这些研究工作需要高灵敏度和分辨率以及可变的温度控制。 获得该仪器预计将对该部门的研究工作产生巨大的积极影响。 该工具的使用每年将涉及 5-10 名本科生进行高级研究和类似数量的暑期研究。