MRI: Acquisition of an Advanced FT-IR System for Multi-Disciplinary Research and Training at Oklahoma State University

MRI：俄克拉荷马州立大学购买先进的 FT-IR 系统用于多学科研究和培训

• 批准号: 1338097
• 负责人: Aihua Xie
• 金额: $ 54.17万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1338097&HistoricalAwards=false
• 关键词: MRI; Acquisition; Advanced; FT; IR

This Major Research Instrumentation (MRI) award supports the acquisition of an integrated Fourier transform infrared (FT-IR) system with diverse functions at the Stillwater Campus of Oklahoma State University (OSU). The main FTIR spectrometer is equipped with state-of-the-art optics and electronics resulting in unprecedented accuracy of FTIR data collection. Integration of an array of components, including tunable nanosecond laser, cryogenic system, infrared microscope, focal plane array detector, and temperature controlled attenuated total reflection cell, makes this instrument a rare and one of the most powerful and versatile FTIR systems for biological research. This multi-functional advanced FT-IR system will significantly impact and enable a broad range of research projects, including but not limited to: develop infrared structural biology for structure-function studies of proteins, investigate principles in receptor activation in biological signaling, explore catalytic mechanism of photosynthetic water oxidation for bio-energy, probe structural dynamics of IL-18:IL-18BP complex formation for autoimmune responses, and analyze polymer nanocoatings for biomedical applications. This system will also be used to characterize biopharmaceuticals for vaccine formulations, and investigate cellular responses in endothelial cells that line the interior surface of blood vessels upon sheer stress for bioengineering of artificial heart.This instrument will be housed in the Henry Bellmon Research Center, a recently completed state-of-the- art building dedicated fully to cutting edge multidisciplinary research. The advanced FT-IR system will be used to catalyze the developments and applications of the emerging field of infrared structural biology of proteins that will significantly impact a wide range of research in life sciences, including basic research, bio-energy, and biomedical research. This powerful and versatile instrument will significantly enhance the research not only by a large number of OSU researchers, but also external users, including from California and New York. An annual workshop on Infrared Structural Biology and a new course on "Infrared Biology: FT-IR Spectroscopy and Imaging" will be initiated and offered to train postdocs, graduate and undergraduate students, including many under-represented minorities. To increase the participation and research experience of under-represented minorities, we have established partnerships with Langston University (85% minority students in a historically black college), Northeastern State University (40% minority students with high percentage of native Americans), and two minority programs in Oklahoma State University-Stillwater campus;the Oklahoma Louis Stokes Alliance for Minority Participation (OK- LSAMP) and the Native Americans in Biological Sciences (NABS) Center. Building on the existing strength of the PI, a leader in promoting women in physics, and 6 women and 2 minority team members, continued efforts will be made to encourage, mentor, and train women and minority scientists at the postdoctoral, graduate and undergraduate levels.

该重大研究仪器 (MRI) 奖项支持在俄克拉荷马州立大学 (OSU) 斯蒂尔沃特校区购买具有多种功能的集成傅里叶变换红外 (FT-IR) 系统。主 FTIR 光谱仪配备了最先进的光学和电子设备，从而实现了 FTIR 数据收集前所未有的准确性。一系列组件的集成，包括可调谐纳秒激光器、低温系统、红外显微镜、焦平面阵列探测器和温控衰减全反射池，使该仪器成为罕见的、用于生物研究的最强大、最通用的 FTIR 系统之一。这种多功能先进的 FT-IR 系统将显着影响并促进广泛的研究项目，包括但不限于：开发用于蛋白质结构功能研究的红外结构生物学、研究生物信号传导中受体激活的原理、探索催化研究光合水氧化产生生物能源的机制，探索 IL-18:IL-18BP 复合物形成的结构动力学以实现自身免疫反应，并分析用于生物医学应用的聚合物纳米涂层。该系统还将用于表征疫苗配方的生物制药，并研究人造心脏生物工程中血管内表面内皮细胞在纯粹应力下的细胞反应。该仪器将安装在亨利贝尔蒙研究中心，最近竣工的最先进的建筑完全致力于尖端的多学科研究。先进的傅里叶变换红外系统将用于促进蛋白质红外结构生物学新兴领域的发展和应用，这将对生命科学研究的广泛研究产生重大影响，包括基础研究、生物能源和生物医学研究。这种功能强大且多功能的仪器不仅将显着增强大量俄勒冈州立大学研究人员的研究，而且还将显着增强包括来自加利福尼亚州和纽约州在内的外部用户的研究。将启动红外结构生物学年度研讨会和“红外生物学：傅立叶变换红外光谱和成像”新课程，并提供培训博士后、研究生和本科生，包括许多代表性不足的少数族裔。为了增加代表性不足的少数族裔的参与和研究经验，我们与兰斯顿大学（85% 的少数族裔学生就读于历史悠久的黑人大学）、东北州立大学（40% 的少数族裔学生，美国原住民比例较高）和两所大学建立了合作伙伴关系。俄克拉荷马州立大学斯蒂尔沃特校区的少数民族项目；俄克拉荷马州路易斯斯托克斯少数民族参与联盟 (OK-LSAMP) 和美国原住民生物科学 (NABS) 中心。基于 PI（一名推动女性物理学领域发展的领导者）以及 6 名女性和 2 名少数族裔团队成员的现有实力，将继续努力鼓励、指导和培训博士后、研究生和本科生级别的女性和少数族裔科学家。