MRI/RUI-Acquisition of A High Field NMR for Chemistry Research

MRI/RUI - 获取用于化学研究的高场 NMR

• 批准号: 0320687
• 负责人: Robin Kinnel
• 金额: $ 23.84万
• 依托单位: Hamilton College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0320687&HistoricalAwards=false
• 关键词: MRI; RUI; Acquisition; Field; NMR

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Hamilton College will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out research on a) the stereochemistry of bromoallene formation in marine algae; b) investigation of the chemical ecology of asters and the butterflies that use them as host plants; c) isolation and structure of bioactive substances from a sponge; d) a conformational study of synthetic peptides that mimic the minimal active sequence of alpha fetoprotein; e) the development of synthetic methodology and mechanistic studies in free radical chemistry; and f) probing the nature of the nitric oxide oxidation of neurotransmitters. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in marine studies, synthetic organic chemistry and biochemistry.

通过主要研究工具（MRI）计划的奖项，汉密尔顿学院化学系将获得400 MHz NMR光谱仪。该设备将使研究人员能够对a）海洋藻类溴形成的立体化学进行研究； b）研究使用它们作为宿主植物的紫色化学生态学和蝴蝶的化学生态； c）从海绵中生物活性物质的分离和结构； d）对合成肽的构象研究，该研究模仿α胎蛋白的最小活性序列； e）在自由基化学中的合成方法和机理研究的发展； f）探测神经递质一氧化氮氧化的性质。 核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具。它用于识别未知物质，以表征分子中原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。这些NMR研究的结果将在海洋研究，合成有机化学和生物化学中产生影响。