与大脑功能与精神障碍有关的多层次多尺度模型的建立与动力学研究

Current research on brain disease is highly focused on the memory impairment with some organic cause, psychiatric disorders by fear memory and abnormal discharge of neurons by brain dysfunction as an important basis of nerve diseases. It needs to better understand and explore physiological mechanism and further develop more effective treatments of diagnosis. Combined with the physiological mechanism of brain functional and mental disorders, we strive to construct several multi-scale dynamical models to investigate internal mechanism of relevant dynamic processes by means of nonlinear dynamics theory and methods in this project. More details are listed as follows: (1) Establishment or improvement of molecular mechanism models of long-term memory formation, especially those dependent on non-coding RNA regulation, and dynamics on different parameter controls on bifurcations, noise, time delays et al; (2) Establishment of multi-level dynamical models of synaptic plasticity involved in fear memory when combined gene expression and regulation with neuronal firing activity, and establishment of neural network model in different regions and its synchronization behavior; (3) Establishment or improvement of neuronal mass models of epileptic abnormal discharge with various deterministic and stochastic factors as well as bifurcation mechanisms and stochastic dynamics, and kinetics of epileptic initiation and termination and different classifications of epilepsy. The study will not only help reveal dynamic nature related to the brain and brain disease pathogenesis mechanism, but also further expand theory and methods of nonlinear dynamics to promote advancement of Dynamics and Control, since it covers complex dynamical characteristics with multiple levels from microscopic, mesoscopic to macroscopic and multiple time scales.

当前高度关注脑疾病的研究，特别是记忆功能减退的器质性障碍、恐惧记忆形成的精神障碍以及脑功能障碍引起神经元异常放电是很多神经疾病的重要基础,需要更好地探索与此有关的生理机制。本申请项目借助非线性动力学理论和方法，建立跨层次多尺度的动力学模型探讨其动力学过程的本质行为。主要包括：(1)非编码RNA调控记忆形成的分子机制模型的建立或改进及诱导不同分岔出现的参数调控，噪声，时滞等动力学研究；(2)与恐惧记忆的突触可塑性机制相关的神经元电活动和基因表达调控相结合的跨层次模型以及不同脑区同步行为的神经网络模型的建立；(3)确定性和随机性因素的癫痫异常放电的神经元集群模型的建立或改进，分岔分析与随机性动力学结合的机理研究；癫痫产生与结束和不同癫痫分类的多时间尺度行为。该研究有助于揭示神经障碍的发病机理，而且涉及到从微观，介观到宏观的多层次以及多时间尺度的复杂动力学特性，扩展非线性动力学的理论与方法。

记忆功能减退的器质性障碍、恐惧记忆形成的精神障碍以及脑功能障碍引起神经元异常放电是很多神经疾病的重要基础,需要更好地探索与此有关的生理机制。本项目借助非线性动力学理论和方法，建立跨层次多尺度的动力学模型探讨其动力学过程的本质行为。主要包括：(1)长期记忆形成的非编码RNA调控机制建模及噪声，时滞等动力学研究；(2)与恐惧记忆的突触可塑性机制相关的，神经元电活动机制与细胞内基因表达与调控的跨层次建模与动力学分析；(3)与癫痫异常放电有关的的神经兴奋性机制，多时间尺度簇放电拓扑类型以及星形胶质细胞钙振荡行为研究. 另外，我们还发展了一些有关神经疾病发病机制有关的表观遗传方面的动力学建模与分析的研究成果。本项目的研究成果有助于揭示神经障碍的发病机理，而且涉及到多层次以及多时间尺度的复杂动力学特性，扩展非线性动力学的理论与方法。

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