Towards a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines

更好地了解五氟硫基对醇和胺的亲脂性和酸/碱性质的影响

• 批准号: 571856-2021
• 负责人: Paquin, JeanFrançoisJF
• 金额: $ 1.82万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748630
• 关键词: Towards; better; understanding; effect; pentafluorosulfanyl

This project aims to gain a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines. In this international collaboration, Prof. Jean-François Paquin from Université Laval (Canada) propose to team up with Prof. Bruno Linclau from Ghent University (Belgium) to tackle this endeavour. Prof. Paquin's research group focuses on synthetic organofluorine chemistry with a particular expertise in the synthesis of SF5-containing compounds while Prof. Linclau's research is focused on investigating how fluorination of organic compounds can modify their physical properties, with a focus on hydrogen bonding, lipophilicity, and conformation. This collaboration brings together two highly regarded research groups in their respective field to work on a project that could lead to very impactful discoveries in drug discovery.

该项目旨在更好地了解五氟硫基对醇和胺的亲脂性和酸/碱性质的影响。在这项国际合作中，来自加拿大拉瓦尔大学的 Jean-François Paquin 教授提议与该项目合作。来自根特大学（比利时）的 Bruno Linclau 教授致力于解决这一问题，Paquin 教授的研究小组专注于合成有机氟化学，具有特殊的专业知识。 Linclau 教授的研究重点是研究有机化合物的氟化如何改变其物理性质，重点是氢键、亲脂性和构象。此次合作汇集了两个备受推崇的研究小组。他们各自的领域致力于一个项目，该项目可能会在药物发现方面带来非常有影响力的发现。