Exploiting XtalFluor reagents in organic synthesis and developing new approaches to pentafluorosulfanyl-containing molecules

在有机合成中利用 XtalFluor 试剂并开发含五氟硫基分子的新方法

• 批准号: 572205-2022
• 负责人: Paquin, JeanFrançoisJF
• 金额: $ 3.72万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748629
• 关键词: Exploiting; XtalFluor; reagents; organic; synthesis

The projects described herein aim at the development of new synthetic tools for the preparation of organic compounds, in particular fluorine-containing molecules which are of high interest in pharmaceutical industry, in agrochemistry as well as in material sciences. Specific objectives are: 1) the improvement of the deoxofluorination reaction using OmegaChem's XtalFluor reagents; 2) the discovery of new transformations using OmegaChem's XtalFluor reagents for the synthesis of fluorinated (sulfonyl fluorides) and non-fluorinated compounds (acyl halides); and 3) the development of novel synthetic approaches to pentafluorosulfanyl-containing compounds. Overall, these projects are significant in the context that OmegaChem is continually working to introduce on the market new molecules that can be integrated to the design of more complex structures demonstrating innovative properties and increased efficiency.

本文描述的项目旨在开发用于制备有机化合物的新合成工具，特别是在制药工业、农业化学以及材料科学中备受关注的含氟分子。具体目标是： 1) 使用 OmegaChem 的 XtalFluor 试剂改进脱氧氟化反应； 2) 发现使用 OmegaChem 的 XtalFluor 试剂合成氟化（磺酰氟）和非氟化化合物（酰基卤）的新转化； 3）开发含五氟硫基化合物的新合成方法。总的来说，这些项目意义重大，因为 OmegaChem 不断致力于向市场推出新分子，这些新分子可以集成到更复杂结构的设计中，展示创新特性和提高效率。