Development of electrophilic fluorination reagents and application of xtalfluor in organic synthesis

亲电氟化试剂的研制及其在有机合成中的应用

• 批准号: 453165-2013
• 负责人: Paquin, JeanFrançois
• 金额: $ 2.37万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=597187
• 关键词: Development; electrophilic; fluorination; reagents; application

The projects describe herein aim at the development of new synthetic tools, either reactions or reagents, for the preparation of organic compounds, in particular fluorine-containing molecules which are of high interest in pharmaceutical and material sciences as well as in agrochemistry. Specific objectives are the development of new chemistry using OmegaChem's reagents XtalFluor for the synthesis of fluorinated (monofluoroalkenes and aryl fluorides) and non-fluorinated compounds (halogenoalkanes, amides, isonitriles and biaryls). In addition, the elaboration of novel electrophilic sources of fluorine will be pursued.

本文描述的项目旨在开发新的合成工具，无论是反应还是试剂，用于制备有机化合物，特别是在制药和材料科学以及农业化学中引起高度关注的含氟分子。具体目标是使用 OmegaChem 的 XtalFluor 试剂开发新化学，用于合成氟化（单氟烯烃和芳基氟化物）和非氟化化合物（卤代烷烃、酰胺、异腈和联芳基化合物）。此外，还将致力于开发新型亲电子氟源。