Organofluorine Chemistry: From New Synthetic Methods to New Reactivity

有机氟化学：从新合成方法到新反应性

• 批准号: RGPIN-2020-04265
• 负责人: Paquin, JeanFrançois
• 金额: $ 6.85万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=716916
• 关键词: Organofluorine; Chemistry; New; Synthetic; Methods

The unique properties of fluorine are key in why this atom and fluorinated groups (CF3, CF2H, etc.) are now key substituents on organic compounds for applications in chemical biology, in medicinal chemistry, in agrochemistry, and in the material sciences. This field needs a deeper fundamental understanding of fluorinated molecule reactivity, and innovative, practical methods for their synthesis. The long-term vision of my research program is to contribute state-of-the-art methods for the synthesis of organofluorine molecules, and to broaden the collective knowledge of the reactivity/behaviour of this unique class of compounds. During the last funding period, we accomplished significant advances that have improved synthetic, medicinal, and bioorganic chemistry. This Discovery Grant renewal will continue this successful program. We intend to concentrate our efforts in the next five years in three major research areas with significant high-impact potential: 1) Exploring new frontiers in the synthesis of pentafluorosulfanylated compounds 2) Exploiting the CF bond as a directing group 3) Improving the synthesis of monofluoroalkenes

氟的独特特性是为什么这种原子和氟化基（CF3，CF2H等）现在是有机化合物，用于化学生物学，药物化学，农业化学和材料科学的关键取代基。 该领域需要对氟化分子的反应性以及其合成的创新，实用方法的更深入的理解。我的研究计划的长期视野是为合成有机氟分子的最新方法贡献最新方法，并扩大对这种独特化合物的反应性/行为的集体知识。在最后一个资金期间，我们取得了重大进步，这些进步改善了合成，药用和生物有机化学。这一发现赠款续签将继续该成功计划。我们打算在未来五年内在具有巨大高影响力的三个主要研究领域集中精力： 1）在合成五氟磺酰化化合物的合成中探索新的边界 2）利用CF债券作为指导组 3）改善单氟烷烃的合成