Metal Mediated and Catalyzed Organic Synthetic Methods

金属介导和催化的有机合成方法

• 批准号: RGPIN-2022-04761
• 负责人: Green, James
• 金额: $ 1.75万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748461
• 关键词: Metal; Mediated; Catalyzed; Organic; Synthetic

The purpose of this proposal is the development and application of new organic chemistry synthetic methods, based on organic reactions mediated by transition metal species. The projects proposed in this grant build upon the developments of our previous Discovery Grant and yet investigate new directions. Central to the individual methods under study is the ability of the transition metal unit to make possible transformations either difficult or impossible by normal synthetic methods, by either stabilizing intermediates or by stabilizing products that could not exist in the absence of the transition metal unit, with particular focus on the alkyne-Co2(CO)6 unit. The specific processes focused on will come from the ability of this unit to stabilize positively charged (carbocation) species, and the ability to make triple bond species in ring containing compounds stable. In addition, we intend to study the effects of the alkyne-Co2(CO)6 unit on intermediates with unpaired electrons (radicals), and whether these intermediates are made more useful in synthesis by the presence of the cobalt unit. The underlying mechanistic aspects of the chemistry under study will also be explored. It is ultimately intended that the chemistry will developed to the point where the parameters of the chemistry is well understood, and the  the synthesis of selected target compounds will be undertaken, to demonstrate to utility of the method and to make naturally occurring compounds that have seen little attention in terms of synthesis.

该建议的目的是基于过渡金属物种介导的有机反应的新有机化学合成方法的开发和应用。这笔赠款中提出的项目以我们先前的发现赠款的发展为基础，并研究了新的方向。研究中所研究的单个方法的核心是过渡金属单元通过稳定中间体或稳定不存在过渡金属单元不存在的产品而难以或不可能通过正常合成方法使可能的转换的能力，尤其是专注于Alkyne-CO2（CO）6单元。关注的特定过程将来自该单元稳定带正电荷（碳酸盐）物种的能力，以及在包含化合物稳定的环中制成三键物种的能力。此外，我们打算研究Alkyne-CO2（CO）6单元对具有未配对电子的中间体（自由基）的影响，以及是否通过存在钴单元使这些中间体在合成中更有用。还将探讨研究化学的基本机械方面。最终打算将化学的发展发展到对化学的参数得到充分了解的地步，并且将进行所选靶化合物的合成，以证明该方法的实用性并使在合成中很少关注的自然化合物。