Metal Mediated and Catalyzed Organic Synthetic Methods

金属介导和催化的有机合成方法

• 批准号: RGPIN-2016-04946
• 负责人: Green, James
• 金额: $ 1.82万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=652402
• 关键词: Metal; Mediated; Catalyzed; Organic; Synthetic

The objective of the proposed research is to develop and understand a series of novel organic chemical reactions mediated by transition metal complexes or catalyzed by either transition metal complexes or main group compounds. The goals include the development of types of carbon-carbon bond forming reactions not normally readily accomplished by traditional organic chemical processes (i.e., the pattern of reactivity is inverted that which is ‘natural' in most organic compounds), and to prepare and use compounds that could not normally exist if it were not for the presence of the metal unit. In particular the proposed metal catalyzed allylation reactions, in conjunction with other catalytic reactions, are designed for being catalytic methods of giving this inverted pattern of reactivity. The proposed chemistry alkynedicobalt complexes are designed to make possible in extended synthetic chemistry the use of compounds that could not be isolated if not for the cobalt atoms. The ultimate goal for the reactions investigated is to develop the chemistry to the point where it can be used in the synthesis of organic molecules of importance, such as compounds that have potential anti-cancer properties, antileukemic properties, antibacterial or insect antifeedant activity. In many cases, the organic compounds simply have interesting structures, and in other cases the prepared compounds are designed to address or challenge question of the fundamental properties of chemical compounds, such as what makes such a compound stable (or unstable).**

拟议研究的目的是开发和理解一系列由过渡金属复合物介导的新型有机化学反应，或者由过渡金属复合物或主要组化合物催化。目标包括通常不容易通过传统有机化学过程来完成的碳碳键形成类型（即，反应性的模式是反应的，即在大多数有机化合物中是“自然”的），并且如果不存在于金属单元的情况下，则可以准备和使用通常不存在的化合物。尤其是提出的金属催化催化反应，以及其他催化反应，旨在是催化方法的催化方法。所提出的化学醇酸化合物络合物旨在使扩展合成化学的使用使化合物使用，如果不是钴原子，则不能分离出来。研究反应的最终目标是开发化学，以便可以将其用于合成重要性的有机分子，例如具有潜在的抗癌特性，抗无菌特性，抗细菌或抑制抗毒剂活性的化合物。在许多情况下，有机化合物仅具有有趣的结构，在其他情况下，制备的化合物旨在解决或挑战化合物的基本特性，例如使这种化合物稳定（或不稳定）的原因。** **