Modular surface chemistry of green nanoparticles for the next generation of functional materials

用于下一代功能材料的绿色纳米颗粒的模块化表面化学

• 批准号: RGPIN-2019-06433
• 负责人: MoranMirabal, Jose
• 金额: $ 2.62万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748251
• 关键词: Modular; surface; chemistry; green; nanoparticles

This proposal aims to tune the interfacial properties of green nanoparticles (gNPs) to develop the next generation of functional micro/nanostructured materials. The demand for environmental sustainability makes renewable materials key to the development of future consumer products. Plant-derived NPs (e.g, cellulose nanocrystals - CNCs) are especially attractive because they have unique properties that can lead to new materials. However, a key obstacle to the widespread use of gNPs is their lack of reactivity. While many approaches to functionalize gNPs exist, they are expensive, require harsh processing, or limit functional diversity. This has severely hindered the use of gNPs in consumer products. Recently, our group proposed to use triazinyl chemistry for the modular functionalization of nanocellulose and showed that its interfacial properties can be readily tailored. Key advantages of this chemistry are that the reactions are done in mild conditions, the functionalization is efficient, and the reagents are inexpensive. The current challenge, which this proposal addresses, is to expand the range of functionalities that can be introduced onto gNPs. We will accomplish this by creating a library of triazinyl derivatives that will be grafted onto renewably-sourced gNPs, rendering them functional, reactive, and/or compatible with a variety of solvents. These new gNPs will be a platform for the development of new materials and products. We will use modified gNPs to develop green photopolymerizable 3D printing bioinks that have tuneable mechanical properties and porosity, and that can be modified post-printing to incorporate biochemical motifs in a spatially and temporally controlled way. 3D printed scaffolds produced using such bioinks will be tested for their suitability in cell culture and tissue engineering. We will also use modified nanomaterials to develop ultraporous microparticles capable of absorbing contaminants or releasing drugs. This will be accomplished by using gNPs bearing two functionalities: on one hand, complementary reactive groups will promote efficient crosslinking, and on the other, binding moieties will allow scavenging heavy metals or slowly releasing antimicrobial agents. Finally, we will use triazinyl chemistry to develop a reactive paper platform that enables the fabrication of complex paper-based microanalytical or electronic devices. This will be done by installing reactive groups on paper that allow us to directly print and covalently immobilize a variety of small molecules, polymers, peptides and nanoparticles, and demonstrating the use of the printed functionalities in the fabrication of sensing devices. The proposed research, including organic synthesis, characterization, and fabrication, and interactions with industrial partners, will provide trainees a rich multidisciplinary environment and highly transferrable skills in chemistry, materials science, micro/nanotechnology, and knowledge translation.

该提案旨在调整绿色纳米粒子（gNP）的界面特性，以开发下一代功能性微/纳米结构材料。对环境可持续性的需求使得可再生材料成为未来消费品开发的关键。植物源纳米粒子（例如纤维素纳米晶体 - CNC）特别有吸引力，因为它们具有可以产生新材料的独特特性。然而，gNP 广泛使用的一个主要障碍是它们缺乏反应性。虽然存在许多使 gNP 功能化的方法，但它们价格昂贵、需要严格的处理或限制功能多样性。这严重阻碍了 gNP 在消费品中的使用。最近，我们的小组提出使用三嗪基化学对纳米纤维素进行模块化功能化，并表明其界面特性可以轻松定制。这种化学的主要优点是反应在温和的条件下进行，官能化是有效的，并且试剂便宜。该提案所解决的当前挑战是扩大可引入 gNP 的功能范围。我们将通过创建一个三嗪基衍生物库来实现这一目标，这些衍生物将接枝到可再生来源的 gNP 上，使它们具有功能性、反应性和/或与各种溶剂兼容。这些新的gNP将成为开发新材料和新产品的平台。我们将使用改性 gNP 开发绿色光聚合 3D 打印生物墨水，该生物墨水具有可调节的机械性能和孔隙率，并且可以在打印后进行修改，以空间和时间控制的方式纳入生化图案。使用此类生物墨水生产的 3D 打印支架将测试其在细胞培养和组织工程中的适用性。我们还将使用改性纳米材料来开发能够吸收污染物或释放药物的超多孔微粒。这将通过使用具有两种功能的 gNP 来实现：一方面，互补的反应基团将促进有效的交联，另一方面，结合部分将允许清除重金属或缓慢释放抗菌剂。最后，我们将使用三嗪基化学来开发反应性纸平台，该平台能够制造复杂的纸基微分析或电子设备。这将通过在纸上安装反应基团来实现，这些基团使我们能够直接打印和共价固定各种小分子、聚合物、肽和纳米颗粒，并演示打印功能在传感设备制造中的使用。拟议的研究，包括有机合成、表征和制造，以及与工业合作伙伴的互动，将为学员提供丰富的多学科环境和化学、材料科学、微/纳米技术和知识转化方面的高度可转移的技能。