Modular surface chemistry of green nanoparticles for the next generation of functional materials

用于下一代功能材料的绿色纳米颗粒的模块化表面化学

• 批准号: RGPIN-2019-06433
• 负责人: MoranMirabal, Jose
• 金额: $ 2.62万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748251
• 关键词: Modular; surface; chemistry; green; nanoparticles

This proposal aims to tune the interfacial properties of green nanoparticles (gNPs) to develop the next generation of functional micro/nanostructured materials. The demand for environmental sustainability makes renewable materials key to the development of future consumer products. Plant-derived NPs (e.g, cellulose nanocrystals - CNCs) are especially attractive because they have unique properties that can lead to new materials. However, a key obstacle to the widespread use of gNPs is their lack of reactivity. While many approaches to functionalize gNPs exist, they are expensive, require harsh processing, or limit functional diversity. This has severely hindered the use of gNPs in consumer products. Recently, our group proposed to use triazinyl chemistry for the modular functionalization of nanocellulose and showed that its interfacial properties can be readily tailored. Key advantages of this chemistry are that the reactions are done in mild conditions, the functionalization is efficient, and the reagents are inexpensive. The current challenge, which this proposal addresses, is to expand the range of functionalities that can be introduced onto gNPs. We will accomplish this by creating a library of triazinyl derivatives that will be grafted onto renewably-sourced gNPs, rendering them functional, reactive, and/or compatible with a variety of solvents. These new gNPs will be a platform for the development of new materials and products. We will use modified gNPs to develop green photopolymerizable 3D printing bioinks that have tuneable mechanical properties and porosity, and that can be modified post-printing to incorporate biochemical motifs in a spatially and temporally controlled way. 3D printed scaffolds produced using such bioinks will be tested for their suitability in cell culture and tissue engineering. We will also use modified nanomaterials to develop ultraporous microparticles capable of absorbing contaminants or releasing drugs. This will be accomplished by using gNPs bearing two functionalities: on one hand, complementary reactive groups will promote efficient crosslinking, and on the other, binding moieties will allow scavenging heavy metals or slowly releasing antimicrobial agents. Finally, we will use triazinyl chemistry to develop a reactive paper platform that enables the fabrication of complex paper-based microanalytical or electronic devices. This will be done by installing reactive groups on paper that allow us to directly print and covalently immobilize a variety of small molecules, polymers, peptides and nanoparticles, and demonstrating the use of the printed functionalities in the fabrication of sensing devices. The proposed research, including organic synthesis, characterization, and fabrication, and interactions with industrial partners, will provide trainees a rich multidisciplinary environment and highly transferrable skills in chemistry, materials science, micro/nanotechnology, and knowledge translation.

该建议旨在调整绿色纳米颗粒（GNP）的界面特性，以开发下一代的功能性微/纳米结构材料。对环境可持续性的需求使可再生材料是开发未来消费产品的关键。植物来源的NP（例如纤维素纳米晶体-CNC）特别有吸引力，因为它们具有独特的特性，可以导致新材料。但是，广泛使用GNP的关键障碍是它们缺乏反应性。尽管存在许多功能化GNP的方法，但它们很昂贵，需要严格的处理或限制功能多样性。这严重阻碍了GNP在消费产品中的使用。最近，我们的小组提议使用三唑化学来进行纳米纤维素的模块化功能化，并表明其界面特性可以很容易地定制。该化学的关键优势在于，反应是在轻度条件下进行的，功能化是有效的，并且试剂廉价。该提案所解决的当前挑战是扩大可以引入GNP的功能范围。我们将通过创建一个将嫁接到可重新源的GNP上的三嗪基衍生物库来实现这一目标，从而使它们具有功能，反应性和/或与各种溶剂兼容。这些新的GNP将是开发新材料和产品的平台。我们将使用改进的GNP开发具有可调机械性能和孔隙率的绿色光聚合3D打印生物互联，并且可以在后期和时间控制的方式中修改后期印刷以结合生化基序。使用此类生物界生产的3D印刷脚手架将在细胞培养和组织工程中的适用性进行测试。我们还将使用改良的纳米材料来开发能够吸收污染物或释放药物的超粒度微粒。这将通过使用具有两个功能的GNP来实现：一方面，互补的反应群将促进有效的交联，另一方面，结合部分将允许清除重金属或缓慢释放抗菌剂。最后，我们将使用三唑化学来开发一个反应性纸张平台，该平台可以制造复杂的基于纸张的微分析或电子设备。这将通过在纸上安装反应性组来完成，该基团使我们能够直接打印并共价固定各种小分子，聚合物，肽和纳米颗粒，并证明在制造感应器件中使用印刷功能。拟议的研究，包括有机综合，表征和制造以及与工业伙伴的互动，将为受训者提供丰富的多学科环境以及化学，材料科学，微/纳米技术和知识翻译方面的高度转移技能。