The impact of calorie restriction mimetics on cellular phenotypes triggered by an Alzheimer disease-related presenilin-1 protein splice variant.

热量限制模拟物对阿尔茨海默病相关早老素 1 蛋白剪接变体引发的细胞表型的影响。

• 批准号: 460603
• 负责人: Almendariz Carla
• 金额: --
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-01-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=460603&lang=en
• 关键词: Aging; Alzheimer'S Disease

The aging brain goes through several changes, at the cellular and molecular levels, associated with protein removal through autophagy, lead to the aggregation of misfolded/damaged proteins and eventually to the disruption of the nuclear membrane. The disr

衰老的大脑在细胞和分子水平上经历了一些变化，这些变化与通过自噬去除蛋白质有关，导致错误折叠/受损蛋白质的聚集，并最终导致核膜的破坏。该disr