Interaction of ultrasound cavitation with membranes: Theoretical modelling and experimental characterization

超声空化与膜的相互作用：理论建模和实验表征

• 批准号: RGPIN-2020-04729
• 负责人: Karshafian, Raffi
• 金额: $ 2.04万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=716891
• 关键词: Interaction; ultrasound; cavitation; membranes; Theoretical

Cavitation is present in many physical phenomena and applications: Medical ultrasound imaging; disease targeted drug delivery; blood-brain-barrier opening; high intensity focused ultrasound; and sonothrombolysis. The application of ultrasound-microbubbles as a novel targeted drug delivery strategy has shown promising potential through enhanced permeability and endocytosis. In our research program, we study the phenomenon of cavitation induced through ultrasonically-stimulated bubbles and their interaction with biological membranes such as cell membranes through theoretical and experimental approaches.

空化存在于许多物理现象和应用中：医疗超声成像；疾病针对药物输送；血脑屏障开口；高强度集中超声；和Sonothothrombolysy。超声 - 微泡作为一种新颖的靶向药物输送策略的应用，通过增强的渗透性和内吞作用显示了有希望的潜力。 在我们的研究计划中，我们研究了通过超声刺激的气泡诱导的空化现象，以及它们通过理论和实验方法与生物膜（例如细胞膜）的相互作用。