Ultrasound Guidance and Monitoring of High-power Ultrasound Therapies

高功率超声治疗的超声引导和监测

• 批准号: RGPIN-2014-04548
• 负责人: Tavakkoli, Jahangir(Jahan)
• 金额: $ 1.38万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=708074
• 关键词: Ultrasound; Guidance; Monitoring; power; Therapies

Intensive focused ultrasound (IFUS), that encompasses high intensity focused ultrasound (HIFU) and histotripsy, is a high-power ultrasound therapy modality with a number of promising established and novel clinical applications. Magnetic resonance imaging (MRI) is currently considered as a gold standard imaging method for monitoring and control of HIFU therapy. However, a number of challenging problems including low temporal resolution, high cost, requirement for the use of MRI-compatible parts, and fitting requirement within the confined space of the MRI gantry, prohibited MRI to be adopted as a method of choice for clinical HIFU therapy monitoring and control. Ultrasound imaging is a relatively inexpensive, non-ionizing and real-time imaging modality that could seamlessly be integrated with an IFUS transducer. These attributes make ultrasound imaging a potentially suitable imaging modality for IFUS treatment monitoring and control. The current proposal aims to build upon PI's research activities in the area of ultrasound image-guided IFUS therapy in both modeling/simulation, and experiment/development aspects. The proposed research program is aimed towards: (a) expansion of current nonlinear ultrasound modeling and simulation algorithms, being developed by the PI and his research group, to include accurate and effective 3D nonlinear tissue temperature estimation and HIFU lesion generation dynamics prediction, and (b) expansion of current ultrasound-based methods, being developed by the PI and his research group, to develop new methods for real-time accurate and robust monitoring and control of HIFU therapies in tissue. Successful completion of the proposed research will bring ultrasound imaging into a competing position with the MRI for monitoring and control of HIFU therapies, which will, in turn, lead to a wider acceptance of HIFU as a non- or minimally-invasive therapy modality in a wide range of clinical applications.

强化聚焦超声 (IFUS) 包括高强度聚焦超声 (HIFU) 和组织解剖学，是一种高功率超声治疗方式，具有许多有前景的既定和新颖的临床应用。磁共振成像（MRI）目前被认为是监测和控制 HIFU 治疗的黄金标准成像方法。然而，时间分辨率低、成本高、需要使用 MRI 兼容部件以及 MRI 机架有限空间内的安装要求等一系列具有挑战性的问题阻碍了 MRI 作为临床 HIFU 的选择方法治疗监测和控制。超声成像是一种相对便宜的非电离实时成像方式，可以与 IFUS 传感器无缝集成。这些属性使超声成像成为 IFUS 治疗监测和控制的潜在合适成像方式。目前的提案旨在以 PI 在超声图像引导 IFUS 治疗领域的建模/模拟和实验/开发方面的研究活动为基础。拟议的研究计划旨在：（a）扩展由 PI 及其研究小组开发的当前非线性超声建模和模拟算法，包括准确有效的 3D 非线性组织温度估计和 HIFU 病变生成动力学预测，以及（ b) 扩展 PI 及其研究小组正在开发的当前基于超声的方法，以开发实时准确且稳健地监测和控制组织中 HIFU 治疗的新方法。拟议研究的成功完成将使超声成像与 MRI 处于竞争地位，用于监测和控制 HIFU 治疗，这反过来又会导致 HIFU 作为一种无创或微创治疗方式得到更广泛的接受。临床应用广泛。