PITUITARY GONADAL FUNCTION IN FASTING

禁食时的垂体性腺功能

• 批准号: 2293129
• 负责人: MATTI I BERGENDAHL
• 金额: $ 2.94万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2293129
• 关键词: PITUITARY; GONADAL; FUNCTION; FASTING

A 2-year clinical research and training program in the University of Virginia General Clinical Research Center will consist of at least two separate research areas concerning mechanisms of fasting-associated hypogonadotropism in men and women. The research and training program will be supervised by Dr. Johannes D. Veldhuis (Department of Internal Medicine/Division of Endocrinology and Metabolism, University of Virginia, Charlottesville,VA). In the first study (1st year), the ability of a gonadotropin-releasing hormone (GnRH) pulse generator to avert the hypogonadotropism of fasting will be tested in normal weight men. In additions, the role of endogenous opiate peptides will be evaluated in the same context. In the second study (1st and 2nd year), I will test the hypothesis that fasting increases the negative feedback actions of sex steroids on the gonadal axis, while amplifying their positive feedback effects on the growth hormone (GH) axis, in postmenopausal women. These studies may elicit later evaluation of other hypotheses, such as that fasting affects the female gonadal axis in a stage-of-the-menstrual cycle specific manner (2nd year). Analysis of gonadotropin (LH and FSH) and GH secretory patterns during fasting will be carried out using computer-assisted multiple-parameter deconvolution analysis. This novel biophysical, computer-assisted technique gives the opportunity to calculate the frequency, mass, amplitude, and duration of these hormone secretory episodes as well as estimate subject-specific hormone clearance rates. Examining the secretory pattern of gonadotropins during short-term fasting in men and women should provide important clues to understanding the pathophysiology of diet- and exercise-induced abnormalities in the human reproductive axis.

一项为期两年的临床研究和培训计划 弗吉尼亚州一般临床研究中心将至少两个 有关禁食相关机制的单独研究领域 男性和女人的性发育不全。 研究与培训计划 将由Johannes D. Veldhuis博士监督（内部部门 医学/内分泌与新陈代谢的科，大学 弗吉尼亚州夏洛茨维尔，弗吉尼亚州）。 在第一年（第一年）中 促性腺激素释放激素（GNRH）脉冲发生器的能力 避免禁食的性质子性将以正常体重进行测试 男人。 此外，内源性阿片类肽的作用将是 在相同的情况下进行评估。 在第二个研究（第一年和第二年）中， 我将检验以下假设，即禁食会增加负面反馈 性类固醇在性腺轴上的作用，同时放大他们的 对生长激素（GH）轴的积极反馈影响， 绝经后妇女。 这些研究可能会在以后对其他研究进行评估 假设，例如禁食会影响雌性性腺轴 特定阶段的特定方式（第二年）。 分析 禁食期间的促性腺激素（LH和FSH）和GH分泌模式将 使用计算机辅助多参数解卷积进行 分析。 这种新颖的生物物理，计算机辅助技术给了 计算频率，质量，振幅和持续时间的机会 这些激素分泌发作以及特定于估计的主题 激素清除率。 检查分泌模式 男性和女人的短期禁食期间的促性腺激素应提供 了解饮食和饮食生理学的重要线索 运动引起的人类生殖轴异常。