Chemical and biochemical approaches for the design of functional supramolecular systems

用于设计功能性超分子系统的化学和生物化学方法

• 批准号: RGPIN-2016-03866
• 负责人: Schmitzer, Andreea
• 金额: $ 4.44万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=708602
• 关键词: Chemical; biochemical; approaches; design; functional

To achieve the best energy, time and catalytic performance of biological systems, nature has developed remarkable strategies that rely on self-assembly, structural hierarchy and synergetic properties of individual structural components. These strategies motivate us to conduct bio-inspired research to create molecules and strategies that follow biological examples for specific applications. Our research program aims the fundamental understanding of the underlying mechanisms in the self-assembly of functional systems towards two specific themes: 1) anion transporters to target cell membranes and 2) non covalent interactions in catalysis. These strategies will be used to generate smart supramolecular systems based on our strong expertise in self-assembly, transmembrane transport, organic and bio-organic areas. The first theme of the proposed research program includes the development of anionophores to specifically target cell membranes. We build on our existing expertise and move forcefully into a challenging and promising new direction, in which we focus our efforts on living cells. Efficient synthetic routes and first-hand experience with diverse families of anionophores developed in our group have the potential to yield new compounds that with uncovered new applications of anion transporters, as tools to study the relationship between their activity in mitochondria and their antibiotic properties. This work will yield new ways to deliver and target therapeutics. The second research theme focuses on the development of supramolecular catalytic processes, where new functionalities/properties are explored for the design of new task-specific supramolecular catalysts. We will apply the fundamental knowledge acquired in the studies to identify and optimize the best hybrid systems to perform different metal-catalyzed reactions, eventually in water. The molecular-level understanding of biological activity and chemical reactivity in complex environments will enable construction and application of supramolecular architectures for precise catalytic applications. The results of the proposed research program will lead to an enhanced understanding of the design principles developed by nature in the course of evolution, will bring new strategies in supramolecular chemistry and will significantly strengthen our ability to generate functional molecules with advanced properties.

为了实现生物系统的最佳能量、时间和催化性能，大自然已经开发出依赖于自组装、结构层次和各个结构组件的协同特性的卓越策略。这些策略激励我们进行仿生研究，以创建遵循特定应用的生物学实例的分子和策略。我们的研究计划旨在从根本上了解功能系统自组装的基本机制，以实现两个特定主题：1）目标细胞膜的阴离子转运蛋白和2）催化中的非共价相互作用。基于我们在自组装、跨膜运输、有机和生物有机领域的强大专业知识，这些策略将用于生成智能超分子系统。 拟议研究计划的第一个主题包括开发专门针对细胞膜的阴离子载体。 我们以现有的专业知识为基础，强力迈向具有挑战性和前景的新方向，其中我们将重点放在活细胞上。我们小组开发的不同阴离子载体家族的高效合成路线和第一手经验有可能产生新的化合物，这些化合物揭示了阴离子转运蛋白的新应用，作为研究其在线粒体中的活性与其抗生素特性之间关系的工具。这项工作将产生提供和靶向治疗的新方法。 第二个研究主题侧重于超分子催化过程的发展，探索新的功能/特性以设计新的特定任务的超分子催化剂。我们将应用在研究中获得的基础知识来识别和优化最佳混合系统，以最终在水中进行不同的金属催化反应。对复杂环境中生物活性和化学反应性的分子水平理解将使超分子结构的构建和应用成为可能，以实现精确的催化应用。 拟议的研究计划的结果将增强对自然在进化过程中发展的设计原理的理解，将带来超分子化学的新策略，并将显着增强我们生成具有先进特性的功能分子的能力。