Supramolecular assistance of imidazolium salts in Organic/Bioorganic Catalysis and Organized Materials

咪唑盐在有机/生物有机催化和有机材料中的超分子辅助

基本信息

批准号：
262970-2011
负责人：
Schmitzer, Andreea
金额：
$ 4.01万
依托单位：
Université de Montréal
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2015
资助国家：
加拿大
起止时间：
2015-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571307
关键词：
Supramolecular assistance imidazolium salts Organic

项目摘要

The study of functional imidazolium-based supramolecular architectures gives rise to emerging opportunities in chemistry, but also bridges the gap between organic and supramolecular systems in an effort to fully understand the driving forces used to assemble these units in different hierarchies. Imidazolium cation is a critical building block common to the three projects described in this proposal, comprising a research program that spans the disciplines of organic, bioorganic and materials chemistry. Supramolecular assemblies require the construction and manipulation of complex molecular architectures of nanometer-sized dimensions. We use imidazolium salts as ionic liquids (IL) for transition metal catalysis, an area of intense current interest for a wide range of reactions. Solubility of organometallic compounds increases in ILs favouring their use in homogeneous catalysis, and thus are often superior to common organic solvents. We also focus on the physico-chemical properties of these imidazolium salts, two of which that can be highlighted: (i) the formation of carbenoid species; and (ii) the formation of "supramolecules" via electrostatic, H-bonds and/or aromatic stacking interactions. The last property is used to modify the molecular reactivity by the formation of "supramolecular complexes" between different guests (reactive species) and these cationic receptors. We are also interested to study newly synthesized imidazolium-metal complexes for medicinal applications in the presence of macrocyclic molecules, as well as the development of synthetic imidazolium-based anion transport systems that operate in vesicle and cell membranes.

对基于咪唑的功能性超分子结构的研究为化学领域带来了新的机遇，同时也弥合了有机系统和超分子系统之间的差距，以充分理解用于在不同层次结构中组装这些单元的驱动力。咪唑鎓阳离子是本提案中描述的三个项目所共有的关键组成部分，其中包括一个涵盖有机、生物有机和材料化学学科的研究项目。超分子组装体需要构建和操纵纳米尺寸的复杂分子结构。我们使用咪唑鎓盐作为离子液体 (IL) 进行过渡金属催化，这是目前广泛关注的反应领域。有机金属化合物在离子液体中的溶解度增加，有利于它们在均相催化中的使用，因此通常优于普通有机溶剂。我们还关注这些咪唑鎓盐的物理化学性质，其中两个值得强调：（i）类胡萝卜素的形成； (ii)通过静电、氢键和/或芳香堆积相互作用形成“超分子”。最后一个特性用于通过在不同客体（反应性物种）和这些阳离子受体之间形成“超分子复合物”来改变分子反应性。我们还有兴趣研究新合成的咪唑鎓金属络合物在大环分子存在下的医学应用，以及开发在囊泡和细胞膜中运行的合成咪唑鎓阴离子传输系统。