Supramolecular assistance of imidazolium salts in Organic/Bioorganic Catalysis and Organized Materials

咪唑盐在有机/生物有机催化和有机材料中的超分子辅助

基本信息

批准号：
262970-2011
负责人：
Schmitzer, Andreea
金额：
$ 4.01万
依托单位：
Université de Montréal
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2015
资助国家：
加拿大
起止时间：
2015-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571307
关键词：
Supramolecular assistance imidazolium salts Organic

项目摘要

The study of functional imidazolium-based supramolecular architectures gives rise to emerging opportunities in chemistry, but also bridges the gap between organic and supramolecular systems in an effort to fully understand the driving forces used to assemble these units in different hierarchies. Imidazolium cation is a critical building block common to the three projects described in this proposal, comprising a research program that spans the disciplines of organic, bioorganic and materials chemistry. Supramolecular assemblies require the construction and manipulation of complex molecular architectures of nanometer-sized dimensions. We use imidazolium salts as ionic liquids (IL) for transition metal catalysis, an area of intense current interest for a wide range of reactions. Solubility of organometallic compounds increases in ILs favouring their use in homogeneous catalysis, and thus are often superior to common organic solvents. We also focus on the physico-chemical properties of these imidazolium salts, two of which that can be highlighted: (i) the formation of carbenoid species; and (ii) the formation of "supramolecules" via electrostatic, H-bonds and/or aromatic stacking interactions. The last property is used to modify the molecular reactivity by the formation of "supramolecular complexes" between different guests (reactive species) and these cationic receptors. We are also interested to study newly synthesized imidazolium-metal complexes for medicinal applications in the presence of macrocyclic molecules, as well as the development of synthetic imidazolium-based anion transport systems that operate in vesicle and cell membranes.

对基于咪唑的功能性超分子体系结构的研究引起了化学的新兴机会，但也弥合了有机和超分子系统之间的差距，以充分了解用于在不同层次结构中组装这些单元的驱动力。咪唑量阳离子是本提案中描述的三个项目共有的关键基础，其中包括一项研究计划，该计划涵盖了有机，生物有机和材料化学的学科。超分子组件需要构建和操纵纳米尺寸尺寸的复杂分子体系结构。我们使用咪唑盐作为离子液体（IL）进行过渡金属催化，这是广泛反应的当前感兴趣的地区。有机金属化合物的溶解度在IL中增加了，促进其在均匀催化中的使用，因此通常优于常见的有机溶剂。我们还专注于这些咪唑盐的物理化学特性，其中两个可以突出显示：（i）甲虫种的形成；（ii）通过静电，H键和/或芳香族堆叠相互作用形成“超分子”。最后一个特性用于通过不同客人（反应性物种）和这些阳离子受体之间的“超分子复合物”的形成来改变分子反应性。我们还有兴趣研究在存在大环分子的情况下用于药用应用的新合成的咪唑金属复合物，以及在囊泡和细胞膜中运行的基于合成的基于咪唑的阴离子传输系统的发展。