Chemical and biochemical approaches for the design of functional supramolecular systems

用于设计功能性超分子系统的化学和生物化学方法

• 批准号: RGPIN-2016-03866
• 负责人: Schmitzer, Andreea
• 金额: $ 4.44万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=664496
• 关键词: Chemical; biochemical; approaches; design; functional

To achieve the best energy, time and catalytic performance of biological systems, nature has developed remarkable strategies that rely on self-assembly, structural hierarchy and synergetic properties of individual structural components. These strategies motivate us to conduct bio-inspired research to create molecules and strategies that follow biological examples for specific applications. Our research program aims the fundamental understanding of the underlying mechanisms in the self-assembly of functional systems towards two specific themes: 1) anion transporters to target cell membranes and 2) non covalent interactions in catalysis. These strategies will be used to generate smart supramolecular systems based on our strong expertise in self-assembly, transmembrane transport, organic and bio-organic areas.***The first theme of the proposed research program includes the development of anionophores to specifically target cell membranes. We build on our existing expertise and move forcefully into a challenging and promising new direction, in which we focus our efforts on living cells. Efficient synthetic routes and first-hand experience with diverse families of anionophores developed in our group have the potential to yield new compounds that with uncovered new applications of anion transporters, as tools to study the relationship between their activity in mitochondria and their antibiotic properties. This work will yield new ways to deliver and target therapeutics.***The second research theme focuses on the development of supramolecular catalytic processes, where new functionalities/properties are explored for the design of new task-specific supramolecular catalysts. We will apply the fundamental knowledge acquired in the studies to identify and optimize the best hybrid systems to perform different metal-catalyzed reactions, eventually in water. The molecular-level understanding of biological activity and chemical reactivity in complex environments will enable construction and application of supramolecular architectures for precise catalytic applications.***The results of the proposed research program will lead to an enhanced understanding of the design principles developed by nature in the course of evolution, will bring new strategies in supramolecular chemistry and will significantly strengthen our ability to generate functional molecules with advanced properties.********

为了实现生物系统的最佳能量，时间和催化性能，自然已经开发了依赖自组装，结构层次结构和单个结构成分的协同特性的非凡策略。这些策略促使我们进行以生物启发的研究为例，以创建遵循特定应用的生物学实例的分子和策略。我们的研究计划的目的是对功能系统自组装中的基本机制的基本理解朝着两个特定主题：1）靶向细胞膜的阴离子转运蛋白和2）催化中的非共价相互作用。这些策略将根据我们在自组装，跨膜运输，有机和生物有机区域方面的强大专业知识来生成智能超分子系统。膜。 我们以现有的专业知识为基础，并有力地朝着充满挑战和有希望的新方向发展，在这种方向上，我们将精力集中在活细胞上。在我们组中开发的多种阴离子家族的有效合成途径和第一手经验有可能产生新的化合物，这些化合物发现了带阴离子转运蛋白的新应用，作为研究其在线粒体中的活性与抗生素特性之间关系的工具。这项工作将产生新方法来交付和靶向治疗剂。我们将应用研究中获得的基本知识来识别和优化最佳的杂种系统，以执行不同的金属催化反应，最终在水中。在复杂环境中对生物学活性和化学反应性的分子级别的理解将使超分子体系结构用于精确的催化应用。在进化过程中，将带来超分子化学的新策略，并将显着增强我们具有先进特性的功能分子的能力。**********