Point-of-care COVID-19 sensor for rapid, large-scale testing

用于快速、大规模测试的床旁 COVID-19 传感器

• 批准号: 555165-2020
• 负责人: Gupta, Manisha
• 金额: $ 3.64万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705591
• 关键词: Point; care; COVID; 19; sensor

In this study, we intend to develop an economical, repeatable, reliable, highly accurate biosensor for COVID-19 diagnostic "point-of-care" testing. The rapid transmission from asymptomatic infected people has made COVID-19 such a widespread and deadly pandemic compared to SARS or MERS. Relying on "social-distancing" measures comes at enormous economic and social cost; this type of compliance is not a sustainable long-term solution. Accurate, large-scale affordable testing is imperative until a vaccine is developed and deployed globally. Much like home pregnancy tests, the proposed portable "point-of-care" devices will use a sample (e.g. saliva) to generate immediate and highly accurate results. It will remove the time delays, high costs and bottle necks experienced with the traditional PCR-based testing methods/protocols currently being used for testing. The proposed biosensors will be printed using aerosol jet 3D printer and can economically be scaled while maintaining the quality. The sensor can be deployed quickly at workplaces, schools, hospitals, airports, etc. for immediate test results. Organic transistors work well as biosensors because they can be used in aqueous medium and also demonstrate high sensitivity. These devices are functionalized to detect COVID virus. This device will give a quick measurement of the COVID-19 virus and will use the patient saliva for testing. The device will be a single use disposable one that can be disposed safely after testing. This device will expedite the testing time and also the number of tests that can be performed which is the requirement of the day.

在这项研究中，我们打算开发一种经济、可重复、可靠、高精度的生物传感器，用于 COVID-19 诊断“即时护理”测试。与 SARS 或 MERS 相比，无症状感染者的快速传播使 COVID-19 成为一种广泛而致命的流行病。 依赖“社交距离”措施会带来巨大的经济和社会成本；这种合规性并不是可持续的长期解决方案。在疫苗开发出来并在全球范围内部署之前，必须进行准确、大规模、负担得起的测试。与家庭妊娠测试非常相似，拟议的便携式“护理点”设备将使用样本（例如唾液）来生成即时且高度准确的结果。它将消除目前用于测试的基于 PCR 的传统测试方法/方案所遇到的时间延迟、高成本和瓶颈。所提出的生物传感器将使用气溶胶喷射 3D 打印机进行打印，并且可以在保持质量的同时经济地进行扩展。该传感器可以快速部署在工作场所、学校、医院、机场等处，以便立即获得测试结果。 有机晶体管非常适合作为生物传感器，因为它们可以在水介质中使用，并且还表现出高灵敏度。这些设备具有检测新冠病毒的功能。该设备将快速测量 COVID-19 病毒，并使用患者唾液进行测试。该设备将是一次性设备，可在测试后安全处置。该设备将加快测试时间以及可以执行的测试数量，这是当天的要求。