Improving Vaccine Delivery in Hospitalized Children

改善住院儿童的疫苗接种

• 批准号: 10806029
• 负责人: Mersine Alexis Bryan
• 金额: $ 15.56万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10806029
• 关键词: Acceleration; Address; Applications Grants; Award; COVID-19 pandemic; Child; Childhood; Clinical; Clinical Trials; Clinical Trials Design; Communication; Communication Research; Competence; Consolidated Framework for Implementation Research; Coupled; Data; Dedications; Disease; Disease Outbreaks; Educational workshop; Electronic Health Record; Eligibility Determination; Ensure; Evaluation; Evidence based intervention; Evidence based practice; Future; Goals; Healthcare; Hospitalists; Hospitalization; Hospitalized Child; Hospitals; Immunization; Information Systems; Inpatients; Intervention; Interview; Maps; Measles; Mentors; Mentorship; Methods; Morbidity - disease rate; National Institute of Child Health and Human Development; Nurses; Parents; Pediatric Hospitals; Pediatric Research; Persons; Pharmacists; Phase; Physicians; Population; Primary Care; Public Health; Registries; Research; Research Personnel; Risk; Sampling; Site; Surveys; Technology; Testing; Training; Translating; Translations; United States Dept. of Health and Human Services; Vaccinated; Vaccination; Vaccines; Work; acceptability and feasibility; analytical method; care outcomes; career; career development; clinical practice; contextual factors; design; effectiveness-implementation randomized trial; health communication; health information technology; high risk; implementation outcomes; implementation science; implementation strategy; improved; informant; innovative technologies; intervention refinement; mortality; multidisciplinary; pilot test; point of care; population based; prototype; public health priorities; research and development; skills; success; therapy design; therapy development; transmission process; usability; user centered design; vaccine access; vaccine delivery; vaccine hesitancy

PROJECT SUMMARY/ABSTRACT: This proposal describes a five-year research and career development training plan that will prepare Dr. Bryan to achieve her career goal of becoming an independent pediatric clinical researcher focused on improving healthcare outcomes for hospitalized children by accelerating the translation of evidence-based interventions into clinical practice using innovative technologies. This proposal is focused on improving vaccination rates in hospitalized children, a high priority population and issue for NICHD. Up to 74% of hospitalized children are missing ≥1 non-influenza vaccines. Currently, hospitalization is a missed opportunity to vaccinate as ~2% of hospitalized children receive any non-influenza vaccines. Integrating implementation science and user- centered design methods, Dr. Bryan’s project goal is to design and test a user-centered intervention that optimizes the integration of Immunization Information Systems data into hospital Electronic Health Records to improve vaccine delivery for hospitalized children. In Aim 1, Dr. Bryan will conduct a mixed methods study of a local and national sample of pediatric hospitalists, nurses and pharmacists to identify determinants and contextual factors for an intervention to identify undervaccinated children and offer needed vaccines using the Consolidated Framework for Implementation Research (CFIR). In Aim 2, she will engage with parents, nurses, pharmacists, physicians, and health information technology experts through workshops and rapid cycle prototyping to develop a prototype for a user-centered intervention that meets the user needs and context identified in Aim 1. She will conduct usability testing and expert evaluation to ensure the design meets the requirements prior to the intervention build and workflow integration. In Aim 3, Dr. Bryan will deploy and pilot test the designed intervention to assess feasibility and acceptability for clinicians and parents. This pilot test will inform a future multicenter cluster-randomized effectiveness-implementation trial to improve vaccine delivery in hospitalized children. To complete this research, Dr. Bryan will develop new competencies in: 1) implementation science, 2) user-centered design methods, and 3) technology-based intervention design. To prepare for the future clinical trial to test the developed intervention, she will also develop skills in clinical trials design and analytic methods for vaccine communication during the award period. Dr. Bryan has assembled a multidisciplinary mentorship team with expertise in vaccine communication research, implementation science, user-centered design, and technology-based intervention design. Her mentors are dedicated to ensuring the success of this project and her career development into an independent researcher. By accomplishing the aims in this proposal, Dr. Bryan will address key gaps in our ability to increase vaccination rates in hospitalized children. Ultimately, this proposal will provide Dr. Bryan the skills she needs in implementation science, user- centered design, technology-based intervention design, clinical trials design and analytic methods for health communication for a research career dedicated to improving healthcare outcomes in hospitalized children.

项目摘要/摘要： 该提案描述了一项为期五年的研究和职业发展培训计划，该计划将为Bryan博士做好准备 为了实现她成为一名专注于改善的独立儿科临床研究人员的职业目标 通过加速基于证据的干预措施的翻译，用于住院儿童的医疗保健结果 使用创新技术进入临床实践。该提案的重点是提高疫苗接种率 住院儿童，高优先级人口和NICHD问题。多达74％的住院儿童是 缺少≥1种非影响力的疫苗。目前，住院是一个未接种疫苗的机会 住院的儿童接受任何非影响力的疫苗。整合实施科学和用户 - 以设计方法为中心，布莱恩博士的项目目标是设计和测试以用户为中心的干预措施 优化将免疫信息系统数据集成到医院电子健康记录中 改善住院儿童的疫苗输送。在AIM 1中，Bryan博士将对A进行混合方法研究 儿科住院医生，护士和药剂师的地方和国家样本 干预措施以识别未接种儿童的上下文因素，并使用该疫苗提供所需的疫苗 合并实施研究框架（CFIR）。在AIM 2中，她将与父母，护士， 通过研讨会和快速周期的药剂师，医师和健康信息技术专家 原型为以用户为中心的干预措施开发原型，以满足用户需求和上下文 在AIM 1中确定。她将进行可用性测试和专家评估，以确保设计达到 干预构建和工作流程集成之前的要求。在AIM 3中，Bryan博士将部署和飞行员 测试设计的干预措施，以评估临床医生和父母的可行性和可接受性。此试点测试 将为未来的多中心群集伴随有效性实施试验提供信息，以改善疫苗 在住院儿童中分娩。为了完成这项研究，Bryan博士将在：1中发展新的能力。 实施科学，2）以用户为中心的设计方法和3）基于技术的干预设计。到 为未来的临床试验做准备以测试开发的干预措施，她还将开发临床试验的技能 奖励期间的疫苗通信的设计和分析方法。布莱恩博士已经组装了 多学科心态团队具有疫苗通信研究，实施科学方面的专业知识， 以用户为中心的设计和基于技术的干预设计。她的导师致力于确保 这个项目的成功及其职业发展成为独立研究人员。通过完成 在此提案中，布莱恩博士将解决我们提高住院疫苗率的能力的关键差距 孩子们。最终，该提案将为Bryan博士提供她在实施科学，用户 - 中心设计，基于技术的干预设计，临床试验设计和健康分析方法 致力于改善住院儿童的医疗保健成果的研究职业的沟通。