Advanced sample introduction methods for mass spectrometry

用于质谱分析的先进进样方法

• 批准号: 521373-2018
• 负责人: Oleschuk, Richard
• 金额: $ 17万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=697694
• 关键词: Advanced; sample; introduction; methods; mass

Mass spectrometers possess unparalleled performance for the identification of chemical and biochemical species, in complex samples, at extremely low concentrations. This proposal describes the combination of a revolutionary mass spectrometric sampling interface commercialized by the industrial partner SCIEX, with fiber fabrication techniques at Université Laval and advanced coatings and machining techniques developed at Queen's University. Queen's and Laval have a strong record of materials-based research and its use for chemical sensing, and SCIEX a 40 year history of bringing Canadian University intellectual property to market for mass spectrometry applications. Superhydrophobic and biomimetic materials obtain their novel water loving/fearing, and sorptive characteristics through a combination of both chemical make-up and micro-nano structure. This proposal will develop advanced manufacturing methods to prepare these materials to aid in mass spectrometric sample preparation where for example large arrays of samples (e.g. fluids such as saliva, urine, blood, spinal fluid) can be created and stored as sub-microliter (<0.00000001 L) droplets or dried spots. Thousands of droplets can be "arrayed" in only a matter of seconds. The rapid sample preparation is well suited to the novel mass spectrometric interface (open port probe), a university technology licensed by SCIEX that is able to inject and analyze droplets at speeds as fast as 5 samples per second! The project leverages > $30 million in University and Governmental (Federal and Provincial) investment at Queen's University and Laval. Although this project has a specific aim to combine and develop MS sample preparation and imaging, the organizations believe this is the beginning of larger relationship between SCIEX, Laval and Queen's University concerning mass spectrometric technology development. HQP will benefit considerably through training at SCIEX, and both academic institutions on state-of-the-art manufacturing equipment and analytical instrumentation. The training will position the students as future leaders and innovators which will continue to propel Canada to the forefront of advanced manufacturing and analytical measurement.

质谱仪具有无与伦比的性能，可在复杂样品中以极低的浓度鉴定化学和生化物种。该提案描述了工业合作伙伴Sciex商业化的革命性质谱抽样界面的结合，以及在皇后大学开发的Laval和高级涂料和加工技术的纤维制造技术。皇后区和拉瓦尔（Queen's）和拉瓦尔（Laval）在基于材料的研究及其用于化学敏感性方面的使用记录很强，Sciex是将加拿大大学知识产权带到市场上的40年历史。超疏水和仿生材料通过化学构成和微纳米结构的结合而获得了新颖的水爱/恐惧和令人敬畏的特征。该建议将开发先进的制造方法来制备这些材料，以帮助进行质谱样品制备，例如，可以创建大量样品（例如唾液，尿液，血液，脊柱液体）的大量样品（例如流体），并作为亚微糖（<0.00000001 l）液滴或滴定点进行存储。仅在几秒钟内就可以将数千个液滴“数量”“数组”。快速样品制备非常适合新型的质谱界面（开放端口探针），这是SCIEX许可的大学技术，能够以每秒5个样本的速度以5个样本的速度注入和分析液滴！该项目在皇后大学和拉瓦尔（Laval）的大学和政府（联邦和省级）投资中利用> 3000万美元。尽管该项目的特定目的是结合和开发MS样品制备和成像，但组织认为这是Sciex，Laval和Queen's University在质谱技术开发方面之间更大关系的开始。 HQP将通过SCIEX的培训以及有关最先进的制造设备和分析仪器的学术机构的培训可观。培训将使学生成为未来的领导者和创新者，这些领导者和创新者将继续推动加拿大的高级制造和分析测量。