Loading of native and modified phytoglycogen nanoparticles: fundamental studies to improve the solubilization, stabilization and delivery of bioactive molecules

天然和改性植物糖原纳米粒子的负载：改善生物活性分子的溶解、稳定和递送的基础研究

• 批准号: 522017-2017
• 负责人: Dutcher, John
• 金额: $ 12.28万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=697496
• 关键词: Loading; native; modified; phytoglycogen; nanoparticles

The use of molecules from nature in nanotechnology applications provides unique opportunities to achieve safety and sustainability. This is particularly promising when enhanced performance and efficacy is achieved, providing a competitive advantage over artificial or engineered nanomaterials. The proposed research investigates applications of one such promising natural nanotechnology: the natural, sustainable and safe PhytoSpherix (Phx) technology. The Phx particles, extracted and purified from sweet corn, are being commercialized by our partner company, Mirexus Biotechnologies Inc., an emerging Canadian company that is a world leader in personal care applications of Phx. We will investigate new, very promising applications in the solubilisation, stabilization and delivery of bioactive molecules such as flavours, colours and drugs for use in cosmetics, nutrition and biomedicine. The academic research team will use a wide range of experimental techniques, and their unique expertise in the study of biological soft materials and the interaction of bioactives with cells, to address the following questions: 1) Can the bioactive molecules penetrate the highly branched, dense Phx particles? 2) How strongly are the bioactive molecules bound to the Phx particles? 3) What are the best environmental conditions to enhance the loading or release of bioactive molecules? 4) Can modifications to the Phx particles be used to enhance their loading? 5) After bioactives are loaded into Phx particles, are they still biologically active? The answers to these fundamental questions, together with Mirexus' in-depth technical and market knowledge, should significantly accelerate the commercialization of new and improved nutraceutical and biomedical products based on the sustainable Phx technology. This will lead to significant benefits for Canada, ranging from the creation of jobs at Guelph-based Mirexus and other Canadian companies, to improved, natural and safe products for Canadian consumers and patients.

在纳米技术应用中使用自然界的分子为实现安全性和可持续性提供了独特的机会。当实现增强的性能和功效时，这尤其有希望，从而提供相对于人造或工程纳米材料的竞争优势。拟议的研究调查了一种有前景的天然纳米技术的应用：天然、可持续且安全的 PhytoSpherix (Phx) 技术。从甜玉米中提取和纯化的 Phx 颗粒正在由我们的合作伙伴公司 Mirexus Biotechnologies Inc. 进行商业化，这是一家新兴的加拿大公司，是 Phx 个人护理应用领域的世界领先者。我们将研究生物活性分子（例如化妆品、营养品和生物医学中使用的香料、色素和药物）的溶解、稳定和输送方面非常有前景的新应用。学术研究团队将利用广泛的实验技术，以及他们在生物软材料研究以及生物活性物质与细胞相互作用方面的独特专业知识，来解决以下问题：1）生物活性分子能否穿透高度支化、致密的Phx颗粒？ 2) 生物活性分子与 Phx 颗粒的结合强度如何？ 3) 增强生物活性分子负载或释放的最佳环境条件是什么？ 4) 对 Phx 颗粒的修饰可以用来增强其负载吗？ 5）Phx颗粒负载生物活性物质后，它们仍然具有生物活性吗？这些基本问题的答案，加上 Mirexus 深入的技术和市场知识，应该会显着加速基于可持续 Phx 技术的新型和改进的营养保健品和生物医学产品的商业化。这将为加拿大带来重大利益，包括为总部位于贵湖的 Mirexus 和其他加拿大公司创造就业机会，以及为加拿大消费者和患者提供改进、天然和安全的产品。