Investigating Particle Size, Colloidal Stability, and Zeta Potential of Colloidal Materials and Macromolecules

研究胶体材料和大分子的粒径、胶体稳定性和 Zeta 电位

• 批准号: RTI-2020-00807
• 负责人: Gates, Byron
• 金额: $ 9.98万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693488
• 关键词: Investigating; Particle; Size; Colloidal; Stability

These funds will enable purchase of critically important equipment for materials chemistry research; a system for particle size analysis (PSA) and zeta potential measurements. This system is necessary to characterize the properties of colloidal materials (e.g., dispersions of particles or macromolecules) or surface charges of thin films. Properties to be assessed include the ability of a particle to remain dispersed in solution as a function of changes in temperature or composition of the solution. Other properties to be examined include particle size distributions as a function of composition or processing conditions, and the charges associated with colloidal species. The equipment also enables the characterization of the stability of these colloidal materials over time, after exposure to harsh chemicals, or at elevated temperatures. Materials of interest include macromolecules used in fuel cells, molecular assemblies for display and sensing applications, and polymer assemblies for in vivo delivery of therapeutic molecules. Additional materials of interest include custom prepared particles to further enable on demand or otherwise controlled release of molecular species, labelling of biological tissues, or the development of new catalysts and membrane materials. The requested system will enable development (e.g., tests to guide scientists in making chemical modifications) and quality control (e.g., tests that assure reproducibility) of these materials.******This system is urgently needed to replace a failed unit that had been used heavily on a daily basis to guide the research of highly qualified personnel (HQP) at Simon Fraser University. The requested system will allow researchers to determine distribution of particles by their size, particle concentrations, sample polydispersity, sample flow, and zeta potentials of a suspension of particles (a colloid). In addition, it will handle small amounts of valuable samples, and will be used to obtain isoelectric points of solid, planar materials through zeta potential analyses (e.g., key information for characterizing fuel cell membranes and modified electrodes).******On an annual basis, ~52 HQP will receive hands-on training and access to this equipment, thereby gaining skills in the use of highly specialized instruments. This will enable them to optimize synthetic processes and gain the ability to correlate sample composition, process conditions, colloidal properties, aging, and reproducibility.******Canadians will benefit from this characterization of colloidal and solid materials as it will enables scientists to build new and better materials for use in clean energy systems, for advanced sensors, and for improved therapeutic agents. Specific examples include materials that improve the energy efficiency and durability of fuel cells, as well as fine-tuned systems for efficient delivery and targeted release of molecular species. This system will also lead to new knowledge in the chemical and materials sciences.

这些资金将使材料化学研究非常重要的设备购买；用于粒度分析的系统（PSA）和ZETA电位测量。该系统对于表征胶体材料（例如颗粒或大分子的分散体）或薄膜表面电荷的特性是必要的。要评估的属性包括粒子保持在溶液中的能力，这是温度变化或溶液组成的变化的函数。要检查的其他特性包括粒度分布，这是组成或加工条件的函数，以及与胶体物种相关的电荷。该设备还可以表征这些胶体材料随着时间的推移，暴露于苛刻的化学物质或温度升高后的稳定性。感兴趣的材料包括用于燃料电池中的大分子，用于显示和传感应用的分子组件以及用于体内治疗分子的聚合物组件。感兴趣的其他材料包括定制准备的颗粒，以进一步启用需求或以其他方式释放分子物种的释放，生物组织的标记或新催化剂和膜材料的发展。请求的系统将使开发（例如，指导科学家进行化学修改）和质量控制（例如，可确保可重复性的测试）的开发。所请求的系统将允许研究人员通过颗粒的大小，颗粒浓度，样品多分散性，样品流量和ZETA电位（胶体）（胶体）的Zeta电位来确定颗粒的分布。此外，它将处理少量的有价值的样品，并通过Zeta潜在分析（例如，表征燃料电池膜和修饰的电极表征表征的关键信息）来获得固体平面材料的等电点。**********每年，〜52 hqp将获得该设备的动力训练和访问该设备，从而可以使用高度专业的仪器，以实现高度专业的培训。这将使他们能够优化合成过程并获得将样品组成，过程条件，胶体性能，老化和可重复性相关联。******加拿大人将受益于这种胶体和固体材料的特征，因为它将使科学家能够在清洁能源系统中构建新​​的和更好的材料，以供高级传感器以及改善的治疗剂。具体示例包括提高燃料电池能效和耐用性的材料，以及用于有效递送和有针对性释放分子物种的微调系统。该系统还将导致化学和材料科学方面的新知识。