Cellular Therapy Bioprocess Engineering

细胞治疗生物过程工程

• 批准号: CRC-2016-00058
• 负责人: Hoesli, Corinne
• 金额: $ 8.74万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693110
• 关键词: Cellular; Therapy; Bioprocess; Engineering

Cellular therapy could reduce health care costs by providing long-lasting treatments to degenerative diseases such as diabetes. The production of cells for transplantation at clinical scale will require the design of novel bioreactors. Efficient stem cell differentiation into functional cells may require signals from a 3D cell culture environment. The objective of the proposed research is to develop bioprocesses to produce therapeutic cells at clinical scale using 3D cell culture. Innovative manufacturing methods such as 3D printing of the biomaterials and cells will help overcome scale-up challenges such as producing organized 3D constructs and supplying oxygen to the cells.

细胞疗法可以通过为糖尿病等退行性疾病提供长期治疗来降低医疗保健成本。临床规模移植细胞的生产需要设计新型生物反应器。干细胞有效分化为功能细胞可能需要来自 3D 细胞培养环境的信号。拟议研究的目标是开发生物工艺，利用 3D 细胞培养在临床规模生产治疗细胞。生物材料和细胞的 3D 打印等创新制造方法将有助于克服规模化挑战，例如生产有组织的 3D 结构和为细胞提供氧气。