Canada Research Chair in Cellular Therapy Bioprocess Engineering / Chaire de recherche du Canada en génie des bioprocédés pour la thérapie cellulaire

加拿大细胞治疗生物过程工程研究主席 / Chaire de recherche du Canada en génie des bioprocédés pour la thérapie cellulaire

• 批准号: CRC-2021-00246
• 负责人: Hoesli, Corinne
• 金额: $ 5.46万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747273
• 关键词: Canada; Research; Chair; Cellular; Therapy; Canada; Research; Chair; Cellular; Therapy

Cellular therapy could reduce health care costs by providing long-lasting treatments to degenerative diseases such as diabetes. The production of cells for transplantation at clinical scale will require the design of novel bioreactors. Efficient stem cell differentiation into functional cells may require signals from a 3D cell culture environment. The objective of the proposed research is to develop bioprocesses to produce therapeutic cells at clinical scale using 3D cell culture. Innovative manufacturing methods such as 3D printing of the biomaterials and cells will help overcome scale-up challenges such as producing organized 3D constructs and supplying oxygen to the cells.

细胞疗法可以通过为糖尿病等退化性疾病提供长期治疗，从而降低医疗保健成本。在临床规模上移植细胞的产生将需要设计新型生物反应器。有效的干细胞分化为功能细胞可能需要来自3D细胞培养环境的信号。拟议的研究的目的是开发生物过程，使用3D细胞培养在临床范围内产生治疗细胞。创新的制造方法（例如生物材料和细胞的3D打印）将有助于克服扩大挑战，例如生产有组织的3D构建体并向细胞供应氧气。