Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
基本信息
- 批准号:RGPIN-2016-06118
- 负责人:
- 金额:$ 1.82万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
***The idea that exercise may produce fat loss without dietary intervention is controversial, as aerobic exercise alone frequently results in fat loss in males but is less effective in females. Recently, we demonstrated an intense model of high-intensity interval training (HIIT) known as sprint interval training (SIT; 4-6 repeated “all-out” 30 s efforts separated by 4 min active rest) induced fat loss in both males and females. However, the magnitude of the fat loss was greater in males. To explore the mechanism for the ability of interval training to induce fat loss, we measured post-exercise metabolism over 24 h across three experimental sessions (no exercise, SIT, moderate-intensity aerobic exercise). Despite the drastically reduced exercise volume (2 min of exercise SIT vs 30 min aerobic), SIT induced a small but prolonged increase in post-exercise metabolism, which likely contributes to the SIT-induced fat loss. However, this increase in post-exercise metabolism is similar across sex. This suggests sex hormones and exercise intensity affect appetite-regulation. ******Appetite regulation involves the integration of the appetite-stimulating (ghrelin) and appetite-inhibiting (PYY, GLP-1) hormones in the brain, which acutely regulate energy intake. While eating and fasting are known to influence these signals, the mechanisms by which sex hormones and exercise affect appetite-regulation are unknown. Thus, the long-term goal of this research program is to improve our understanding of the specific mechanisms responsible for human appetite regulation. As estrogen and progesterone are known to influence energy intake, sex differences likely involve these key sex hormones. Further, while research has demonstrated exercise alters energy intake, the mechanisms responsible remain unclear. The short-term objectives will explore how: 1) sex hormone levels (estrogen, progesterone) during the menstrual cycle affect appetite-regulating hormones; and 2) how the intensity of exercise alters the appetite-regulating hormones due to increases in the skeletal muscle inflammatory marker interleukin-6 (IL-6) and 3) blood lactate (product of muscle metabolism). ******The proposed work will be conducted in humans using serial blood draws (fasted, fed, pre- and post-exercise) over several hours to establish a time course of effects. Specific appetite-regulating hormones (grehlin, PYY, GLP-1) and potential physiological mediators (sex hormones, IL-6, lactate) will be analyzed. This research will improve our understanding of appetite regulation and provide training of numerous highly qualified personnel in exercise physiology, endocrinology, and fitness evaluation/exercise prescription. The long-term impact of this research will provide new insights on appetite regulation to improve strategies to induce body fat loss aiding the treatment of metabolic disorders such as obesity and type II diabetes.
***运动可以在不进行饮食干预的情况下减少脂肪的想法是有争议的,因为单独有氧运动经常导致男性脂肪减少,但对女性效果较差。最近,我们展示了一种高强度间歇训练(HIIT)的强化模型。称为冲刺间歇训练(SIT;4-6 次重复“全力以赴”30 秒的训练,中间间隔 4 分钟的积极休息)可导致男性和女性的脂肪减少,但男性的脂肪减少幅度更大。探索机制尽管运动量显着减少(2 分钟的 SIT 运动与 30 分钟的运动),但我们还是通过三个实验(无运动、SIT、中等强度有氧运动)测量了 24 小时内的运动后代谢。有氧运动),SIT 会引起运动后代谢的小幅但长期的增加,这可能有助于 SIT 引起的脂肪减少,但是,这种运动后代谢的增加在性别之间是相似的。激素和运动强度影响食欲调节 ****** 食欲调节涉及大脑中刺激食欲(生长素释放肽)和抑制食欲(PYY、GLP-1)激素的整合,从而敏锐地调节能量摄入。虽然已知饮食和禁食会影响这些信号,但性激素和运动影响食欲调节的机制尚不清楚。因此,该研究计划的长期目标是提高我们对人类食欲的具体机制的了解。作为雌激素和调节。众所周知,黄体酮会影响能量摄入,性别差异可能涉及这些关键的性激素。此外,虽然研究表明运动会改变能量摄入,但短期目标将探讨:1)性激素水平(雌激素)。 、黄体酮)在月经周期中会影响食欲调节激素;2)运动强度如何因骨骼肌炎症标记物白介素-6 的增加而改变食欲调节激素。 (IL-6) 和 3) 血乳酸(肌肉代谢的产物)********拟议的工作将在几个小时内通过连续抽血(禁食、进食、运动前和运动后)在人体中进行。将分析特定的食欲调节激素(grehlin、PYY、GLP-1)和潜在的生理介质(性激素、IL-6、乳酸)。提供众多高素质人才的培训运动生理学、内分泌学和健身评估/运动处方方面的合格人员这项研究的长期影响将为食欲调节提供新的见解,以改进诱导体脂减少的策略,从而有助于治疗肥胖和 II 型代谢性疾病。糖尿病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Hazell, Tom其他文献
Functional benefit of power training for older adults
- DOI:
10.1123/japa.15.3.349 - 发表时间:
2007-07-01 - 期刊:
- 影响因子:1.5
- 作者:
Hazell, Tom;Kenno, Kenji;Jakobi, Jennifer - 通讯作者:
Jakobi, Jennifer
Hazell, Tom的其他文献
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{{ truncateString('Hazell, Tom', 18)}}的其他基金
Understanding the mechanisms involved in exercise-induced appetite suppression
了解运动引起的食欲抑制的机制
- 批准号:
RGPIN-2022-03991 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
- 批准号:
RGPIN-2016-06118 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
- 批准号:
RGPIN-2016-06118 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
- 批准号:
RGPIN-2016-06118 - 财政年份:2018
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
- 批准号:
RGPIN-2016-06118 - 财政年份:2017
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
- 批准号:
RGPIN-2016-06118 - 财政年份:2016
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
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Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
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Appetite regulation in humans: effect of sex hormones and exercise intensity
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- 资助金额:
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Discovery Grants Program - Individual
Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
- 批准号:
RGPIN-2016-06118 - 财政年份:2018
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Appetite regulation in humans: effect of sex hormones and exercise intensity
人类食欲调节:性激素和运动强度的影响
- 批准号:
RGPIN-2016-06118 - 财政年份:2017
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual