Engineered sugar-based polymers for advanced biomedical applications**********

用于先进生物医学应用的工程糖基聚合物************

• 批准号: 534382-2018
• 负责人: Zhu, Julian
• 金额: $ 1.82万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=669882
• 关键词: Engineered; sugar; based; polymers; advanced

Advanced Polymer Materials Inc. (APM) is a company based in Dorval, QC, manufactures innovative biodegradable and biocompatible specialty polymers to fill the unique R&D needs of customers in pharmaceutical and medical fields. Synthetic sugar group-bearing polymers (glycopolymers) have recently shown interesting potential as alternative replacements of other polymers in drug delivery, the filtration of bacteria such as E. Coli from water through the interactions with sugar-recognizing surface groups. Challenging issues in the synthesis and purification of glycomonomers and polymers limit their commercial availability. Zhu's group at Université de Montréal developed expertise in laboratory scale synthesis and characterization. This 6-month Engage project is proposed to team up APM with Zhu's group in U de M to find solutions to the purification and controllability issues in glycopolymer synthesis, to develop protocols for the synthesis and characterization of a collection of customizable monomers and polymers, and to enlarge the synthetic scale to meet the industrial requirements. Some experiments related to synthetic scaling-up and production will be done in the labs of APM. Pharmaceutical industry in Canada has been strong in R&D and new product development. Through the years, Canada's expertise in this area has often developed through industry-university collaboration. The results will help to improve the competitive edge of the Canadian industry and will bring economic benefits in the form of increased business opportunities and profits, additional employment and tax revenues.

Advanced Polymer Materials Inc.（APM）是一家位于QC Dorval的公司，生产了创新的生物降解和生物相容性的专业，OFILL的顾客在药物领域中的独特R＆D需求显示了与综合替换的人的交流。表面构成的挑战是在纯净的合成和聚合物的纯化中，Zhu群体在Universil的upm中与Zhu upm upm upm的纯化和u de m ups的纯化和可控性合成。与综合缩放和生产有关的一些经验将在APM的实验室中进行。加拿大人将以SS的机会和利润，额外的就业和税收收入的形式获得经济利益。