Versatile Polymeric Biomaterials

多功能高分子生物材料

• 批准号: RGPIN-2014-04762
• 负责人: Zhu, Julian
• 金额: $ 3.93万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=669881
• 关键词: Versatile; Polymeric; Biomaterials

The use of natural compounds can help to improve the biocompatibility and bioacceptance of polymeric biomaterials in their applications. Conjugating signaling agents for cellular recognition is of importance for such materials. We plan to design, synthesize and characterize new polymers containing moieties of natural biocompounds such as bile acids and saccharides and test them for their intended applications. **Oligosaccharide units often serve as signaling agents in cellular membrane for the recognition of cells. Synthetic glycopolymers containing pendant saccharide moieties may be used as multivalent natural oligosaccharide mimics in biological and biomedical applications such as macromolecular drugs and drug delivery systems. We intend to systematically explore the use of glycopolymers with sugar residues designed for cellular interactions and targeted drug delivery. Living radical polymerization methods will be used to make block copolymers with bile acid unit in the more hydrophobic block and with sugar residues such as derivatives of glucosamine in the second block. The properties of such polymers will be studied and optimized for their intended applications.**We have used anionic polymerization method to make block copolymers and would like to expand its use to make a variety of star-shaped copolymers and oligomers followed by functionalization of the end groups or the side groups by attaching glycol-residues/oligosaccharides for use in cellular recognition. In this case, we plan to use cholic acid, one of the major bile acids, as the core to initiate the polymerization and vary the length of the blocks to obtain copolymers with balanced amphiphilic properties. These polymers are expected to possess responsiveness to changes in temperature, pH and ionic strength and may be tested for use as biosensors and drug delivery vehicles.**We would continue to explore the use of enzymes such as lipases in the preparation of degradable polymers through entropy-drive ring-opening polymerization of macrocyclic monomers derived from natural compounds. The use of enzymes can replace the use of catalysts based on heavy metals, ridding the polymers free of residual metals and thus making them more biocompatible. The polymers are known to be useful as shape-memory materials. Our recent discovery of the multiple-shape memory effect of such polymers will be further studied to optimize the molecular design of the polymers and to understand the structure-property relationship.**This research work will help to build a library of new materials suitable for use in tissue engineering, bioseparation, biosensing and drug delivery. The characterization and physico-chemical study of the new polymers should provide an understanding of the properties of materials related to their chemical structures and compositions. The biocompatibility of some of the materials will be tested. The materials will be tested and optimized for their intended applications. We expect that the results obtained are useful and important to both fundamental and practical aspects of polymer chemistry and materials science. The interdisciplinary nature of the proposed work provides an ideal training environment for students in chemistry and biomaterials.

天然化合物的使用可以帮助提高聚合物生物材料在其应用中的生物相容性和生物学感受。与细胞识别的信号传导剂的共轭对于此类材料至关重要。我们计划设计，合成和表征包含天然生物化合物的部分（例如胆汁酸和糖精的部分），并测试其预定应用。 **寡糖单元通常用作细胞膜中识别细胞的信号传导剂。含有吊坠糖部分的合成糖聚合物可以用作生物学和生物医学应用中的多价天然寡糖模拟物，例如大分子药物和药物递送系统。我们打算系统地探索与糖残基的使用，这些糖残基设计用于细胞相互作用和靶向药物递送。生命的自由基聚合方法将用于在更疏水的块中与胆汁酸单位和糖残基，例如第二个区块中葡萄糖胺的衍生物等糖残基。此类聚合物的特性将针对其预期的应用进行研究和优化。通过连接甘体 - 含糖/寡糖用于细胞识别，末端组或侧基组。在这种情况下，我们计划使用胆汁酸，这是主要的胆汁酸之一，作为启动聚合并改变块长度以获得具有平衡两亲性质的共聚物的核心。这些聚合物有望具有对温度，pH和离子强度变化的反应性，可以用作生物传感器和药物输送车的使用。源自天然化合物的大环单体的熵驱动环开环聚合。酶的使用可以取代基于重金属的催化剂，从而使聚合物没有残留金属，从而使它们更具生物相容性。这些聚合物被称为形状内存材料。我们最近将进一步研究此类聚合物的多形记忆效应，以优化聚合物的分子设计并了解结构 - 质体关系。**这项研究工作将有助于建造适合的新材料库用于组织工程，生物序列化，生物传感和药物输送。新聚合物的表征和物理化学研究应提供对与其化学结构和组成相关的材料的特性的理解。某些材料的生物相容性将进行测试。这些材料将针对其预期应用进行测试和优化。我们预计获得的结果对于聚合物化学和材料科学的基本和实际方面都是有用且重要的。拟议工作的跨学科性质为化学和生物材料的学生提供了理想的培训环境。