High-Resolution Continuum Source Atomic Absorption Spectrometry for Environmental and Human Health Research

用于环境和人类健康研究的高分辨率连续源原子吸收光谱法

• 批准号: RTI-2019-00355
• 负责人: Liu, Jinxia
• 金额: $ 10.88万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=657764
• 关键词: Resolution; Continuum; Source; Atomic; Absorption

We are requesting a novel High-Resolution Continuum Source Atomic Absorption Spectrometer (HR CS-AAS) to support research programs that investigate: (i) the fate, transport, effect, and remediation of per- and poly-fluoroalkyl substances (PFASs) in the fields of environmental chemistry, engineering, and microbiology; and (ii) impacts of indoor and outdoor air pollution on human health in the fields of epidemiology and exposure science. The system is urgently needed for two primary applications: sensitive quantitation of organofluorine in environmental and biological samples, and high-throughput analysis of multiple metal elements in air samples. In the first application, HR CS-AAS, which enables sensitive, reliable and fast detection of organofluorine, will allow us to perform comprehensive characterization of PFAS-contaminated samples, for tracking fluorine in novel biochemical reactions that break C-F bonds, and for devising remediation strategies to protect drinking water supplies. Such characterization is time-consuming and challenging; without the instrument, determination of critical parameters is missing from the applicants' current work, and cannot be otherwise achieved. The requested system will enable the highly reputable environmental epidemiology program at McGill to build new research capacity for the measurement of metal species in environmental matrices. The availability of the instrument and the new research capacity will divert a significant portion of sample analysis performed elsewhere back to our labs, enhancing our productivity and providing a new training opportunity for highly qualified personnel (HQP). The environmental research to be supported is extremely timely and significant, and involves the assessment of ecological and health implications of persistent and toxic PFASs that have been widely detected in humans, wildlife and the environment. The health sciences research enabled by the HR CS-AAS will address global challenges of air pollution epidemiology, energy use, industrialization, urbanization, and their direct and indirect links with disease burden and human well-being. The instrument applied for will substantially enhance HQP training and the quality of their research, increasing the competitiveness of the Canadian workforce in addressing urgent environmental and human health problems. The instrument requested will be used in 10 ongoing interdisciplinary projects of global reach, and will enhance the research and innovation capacity of 37 graduate students and postdoctoral fellows.

我们要求新的高分辨率连续源原子吸收光谱仪（HR CS-AAS）支持研究计划：（i）在环境化学，工程，工程，工程学以及微生物学领域的命运，运输，效应和修复效果，运输，效果和修复； （ii）室内和室外空气污染对流行病学和暴露科学领域的人类健康的影响。迫切需要对两个主要应用进行该系统：在环境和生物样品中对有机氟的敏感定量，以及对空气样品中多种金属元素的高通量分析。在第一个应用中，可以使敏感，可靠且快速检测器官氟氨酸的HR CS-AAS使我们能够对PFAS污染样品进行全面的表征，以在新型的生化反应中跟踪C-F键的新生化反应，并破坏C-F键，以及为保护饮用水提供的重新定制策略。这种特征是耗时且具有挑战性的。没有仪器，申请人目前的工作中缺少关键参数的确定，否则就无法实现。所请求的系统将使麦吉尔（McGill）的高知名环境流行病学计划能够建立新的研究能力，以测量环境矩阵中的金属物种。仪器的可用性和新的研究能力将转移到其他地方进行的样本分析的大部分回到我们的实验室，提高我们的生产力，并为高素质的人员（HQP）提供新的培训机会。要支持的环境研究非常及时，很重要，涉及对在人类，野生动植物和环境中广泛检测到的持续性和有毒PFAS的生态和健康影响的评估。 HR CS-AAS实现的健康科学研究将解决空气污染流行病学，能源使用，工业化，城市化及其与疾病负担和人类福祉的直接和间接联系的全球挑战。申请的工具将大大提高HQP培训及其研究质量，从而提高加拿大劳动力在解决紧急环境和人类健康问题方面的竞争力。所要求的仪器将用于全球范围的10个正在进行的跨学科项目，并将增强37名研究生和博士后研究员的研究和创新能力。