Oxytocin receptor PET ligands: imaging the love receptor’s engagement

催产素受体 PET 配体：对爱情受体的参与进行成像

• 批准号: LP220200965
• 负责人: Prof Michael Kassiou
• 金额: $ 50.44万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP220200965
• 关键词: Oxytocin; receptor; PET; ligands; imaging

This project aims to develop a positron emission tomography (PET) ligand for the oxytocin receptor. This novel platform is significant as it will allow the scientific community to answer questions about the role of the oxytocin receptor in the important process of social behaviour which underlies quality of life. This knowledge gap has remained unanswered for decades due to the lack of specific techniques to measure oxytocin receptor engagement. It is also significant as it will equip Australian startup Kinoxis Therapeutics to progress their molecules to market, a process enabled by measuring oxytocin receptor engagement. Our dual expertise on the oxytocin receptor and PET ligand development uniquely situate us to generate this technology.

该项目旨在为催产素受体开发正电子发射断层扫描（PET）配体。这个新颖的平台非常重要，因为它将使科学界能够回答有关催产素受体在生活质量基础的社会行为过程中的作用的问题。由于缺乏测量催产素受体参与的特定技术，因此数十年来，这种知识差距一直没有得到答复。 这也很重要，因为它将为澳大利亚初创企业Kinoxis Therapeutics提供将其分子推向市场，这是通过测量催产素受体参与来实现的过程。我们在催产素受体和宠物配体开发方面的双重专业知识独特地使我们能够生成这项技术。