Radiochemistry Facility for Biomolecule Characterisation in Living Systems

用于生命系统中生物分子表征的放射化学设施

• 批准号: LE230100091
• 负责人: Prof Michael Kassiou
• 金额: $ 66.8万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-06-02 至 2024-06-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE230100091
• 关键词: Radiochemistry; Facility; Biomolecule; Characterisation; Living; Radiochemistry; Facility; Biomolecule; Characterisation; Living

This project will provide a microfluidic radiochemistry facility that fills a critical capability gap in the network of core imaging research laboratories in New South Wales. It will enable the labelling of novel biomolecules with short-lived radioisotopes for their characterisation in living subjects. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets, development of next generation radiochemistry technologies, investigating mechanisms of brain plasticity in predictive learning, developing novel methods for multi-modal image analysis, and understanding the molecular pathways involved in dysregulated cellular networks.

该项目将提供一个微流体放射化学设施，填补新南威尔士州核心成像研究实验室网络中的关键能力差距。这将使新型生物分子具有短寿命的放射性同位素的标记，以在生物中的特征。该平台将使与特定蛋白质靶标结合的新化学探针和纳米颗粒的发展和体内表征一样多样化，下一代放射化学技术的开发，研究预测性学习中大脑可塑性的机制，开发用于多模式图像分析的新方法，以及了解涉及的分子途径涉及涉及的分子途径。