Microbial Ultrastructure

微生物超微结构

• 批准号: 1000231007-2015
• 负责人: Tocheva, Elitza
• 金额: $ 7.29万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643168
• 关键词: Microbial; Ultrastructure

This project describes studies of microbial ultrastructure and how it relates to human health. Two recent technological advances allow for such studies: the development of super-resolution light microscopy and cryo electron tomography. By combining structural biology with microbiology, traditional molecular biology and biochemistry, my lab will focus on the structure-function relationship of the bacterial cell envelope and type IV secretion mechanisms. Unraveling the structural and mechanistic details of membrane biogenesis and secretion will provide novel approaches for developing spore-specific disinfectants (clean rooms and hospital settings), germination blockers (food industry) and therapeutic targets (human health and agriculture).

该项目描述了微生物超微结构及其与人类健康的关系的研究。最近的两项技术进步使得此类研究成为可能：超分辨率光学显微镜和冷冻电子断层扫描的发展。通过将结构生物学与微生物学、传统分子生物学和生物化学相结合，我的实验室将重点研究细菌细胞包膜的结构与功能关系以及IV型分泌机制。揭示膜生物发生和分泌的结构和机制细节将为开发孢子特异性消毒剂（洁净室和医院环境）、发芽阻断剂（食品工业）和治疗目标（人类健康和农业）提供新方法。