Mechanisms of membrane biogenesis and peptidoglycan remodeling during sporulation

孢子形成过程中膜生物发生和肽聚糖重塑的机制

• 批准号: RGPIN-2015-04345
• 负责人: Tocheva, Elitza
• 金额: $ 3.14万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629711
• 关键词: Mechanisms; membrane; biogenesis; peptidoglycan; remodeling

My research program seeks to understand the structural and functional changes that occur in the bacterial cell envelope during growth and cell division. Although bacteria occupy every niche in the biosphere and sustain life on this planet, they are faced with unpredictable environments. To survive, they have evolved a sophisticated, multilayered cell envelope structure composed of either one or two membranes and a mesh-like polymer (peptidoglycan) that protects them while allowing the selective passage of nutrients and waste products. Spatial and temporal regulation of changes in the cell envelope is essential to bacterial growth and division. Moreover, the bacterial cell envelope is a major target for antimicrobials. Thus, research into the bacterial cell envelope provides insight into fundamental biological processes and is critical for understanding human health and disease.

我的研究计划试图了解生长和细胞分裂过程中细菌细胞包膜中发生的结构和功能变化。尽管细菌占据了生物圈中的每个小众市场并在这个星球上维持生命，但它们面临着不可预测的环境。为了生存，它们已经进化出了一个由一个或两个膜和网状聚合物（肽聚糖）组成的复杂的多层细胞包膜结构，该结构可保护它们，同时允许养分和废物的选择性通过。细胞包膜变化的空间和时间调节对于细菌生长和分裂至关重要。此外，细菌细胞包膜是抗菌剂的主要靶标。因此，对细菌细胞包膜的研究提供了对基本生物学过程的见解，对于理解人类健康和疾病至关重要。