Small molecule agonists of the RIG-I pathway as innate stimulatory agents against influenza virus infection

RIG-I 途径的小分子激动剂作为对抗流感病毒感染的先天刺激剂

• 批准号: 183362
• 负责人: Lin Rongtuan
• 金额: $ 7.26万
• 依托单位: CIUSSS de Centre-Ouest-de-l'Ile-de-Montral-Jewish General
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-04-01 至 2010-04-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=183362&lang=en
• 关键词: Avian Influenza A Virus H5n1; Cell Growth; Innate Immunity; Interferon Signaling; Nonstructural Protein 1; Rig-I

The 1918 influenza pandemic accounted for more than 40 million human deaths worldwide. The emergence of highly pathogenic avian influenza strains such as H5N1 has raised global concern about the potential for this virus to evolve into next influenza pande

1918 年流感大流行导致全球超过 4000 万人死亡。 H5N1等高致病性禽流感病毒株的出现引起了全球对这种病毒可能演变成下一种流感大流行的担忧。