Electrochemistry, Spectroscopy and Microscopy for Interdisciplinary Research

用于跨学科研究的电化学、光谱学和显微镜

• 批准号: 261697-2013
• 负责人: Ding, Zhifeng
• 金额: $ 3.93万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632464
• 关键词: Electrochemistry; Spectroscopy; Microscopy; Interdisciplinary; Research

This multidisciplinary proposal involves biological, materials, physical and analytical chemistries, based on our research tools and expertise established at Western. We intend to apply scanning electrochemical microscopy (SECM), electrochemiluminescence (ECL), bipolar electrode (BPE) microfluidics, confocal Raman microspectroscopy, and ionic liquids (ILs) to three new research fields with great application potentials: 1. SECM of live cells and metallic materials. SECM will measure and image reactive oxygen species (ROS) for cell dysfunctions and stimulations by drug molecules. ROS are involved in biological activity in virtually all cells and tissues. We will also use SECM to non-invasively construct grain microstructures of many metallic materials such as Zn, Ni electroplated high strength steels for hot-stamping in manufacturing automobiles. We will correlate the structures to their reactivity for further enhancing product quality to cost ratios. Progresses in analytical instrumentation and nano probe fabrication will be anticipated. 2. ECL microfluidics. For the first time, we will integrate a BPE inside a microfluidic device to measure the cellular ROS concentration that is proportional to ECL intensity. The novel ECL protocol is similar to flow cytometry, but it is no-invasive since extracellular ROS are measured, and has much higher sensitivity because no interference light source is introduced. Clinic applications and practical devices are anticipated. 3. Our hydrophobic and low-cost ILs will be assessed to be electrolytes in Li batteries and electric double layer cells as well as media for electrodeposition of Li electrodes. This will facilitate the fabrication of greener and safer energy storage devices. Our ILs will also be utilized as the main component in membranes of sensitive ion-selective electrodes. All of these research activities will provide excellent opportunities for high quality personnel training, including undergraduate and graduate students. This research will contribute positively to population health, daily life, energy resources and environment in Canada.

这项多学科提案涉及生物、材料、物理和分析化学，基于我们在西方建立的研究工具和专业知识。我们打算将扫描电化学显微镜（SECM）、电化学发光（ECL）、双极电极（BPE）微流控、共焦拉曼显微光谱和离子液体（IL）应用于三个具有巨大应用潜力的新研究领域：1.活细胞和细胞的SECM金属材料。 SECM 将测量细胞功能障碍和药物分子刺激的活性氧 (ROS) 并对其进行成像。 ROS 参与几乎所有细胞和组织的生物活性。我们还将使用 SECM 非侵入性地构建许多金属材料的晶粒微观结构，例如用于制造汽车热冲压的镀锌、镍高强度钢。我们将把结构与其反应性联系起来，以进一步提高产品质量与成本比。预计分析仪器和纳米探针制造将取得进展。 2.ECL微流控。我们首次将 BPE 集成到微流体装置中，以测量与 ECL 强度成正比的细胞 ROS 浓度。新颖的ECL协议类似于流式细胞术，但它是无创的，因为测量细胞外ROS，并且由于不引入干扰光源而具有更高的灵敏度。预计临床应用和实用设备。 3.我们的疏水性和低成本离子液体将被评估为锂电池和双电层电池中的电解质以及锂电极电沉积的介质。这将有助于制造更环保、更安全的储能设备。我们的离子液体还将用作敏感离子选择性电极膜的主要成分。所有这些研究活动都将为高素质人才培养，包括本科生和研究生提供极好的机会。这项研究将为加拿大的人口健康、日常生活、能源资源和环境做出积极贡献。