Electrochemistry, Spectroscopy and Microscopy for Interdisciplinary Research

用于跨学科研究的电化学、光谱学和显微镜

• 批准号: 261697-2013
• 负责人: Ding, Zhifeng
• 金额: $ 3.93万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632464
• 关键词: Electrochemistry; Spectroscopy; Microscopy; Interdisciplinary; Research

This multidisciplinary proposal involves biological, materials, physical and analytical chemistries, based on our research tools and expertise established at Western. We intend to apply scanning electrochemical microscopy (SECM), electrochemiluminescence (ECL), bipolar electrode (BPE) microfluidics, confocal Raman microspectroscopy, and ionic liquids (ILs) to three new research fields with great application potentials: 1. SECM of live cells and metallic materials. SECM will measure and image reactive oxygen species (ROS) for cell dysfunctions and stimulations by drug molecules. ROS are involved in biological activity in virtually all cells and tissues. We will also use SECM to non-invasively construct grain microstructures of many metallic materials such as Zn, Ni electroplated high strength steels for hot-stamping in manufacturing automobiles. We will correlate the structures to their reactivity for further enhancing product quality to cost ratios. Progresses in analytical instrumentation and nano probe fabrication will be anticipated. 2. ECL microfluidics. For the first time, we will integrate a BPE inside a microfluidic device to measure the cellular ROS concentration that is proportional to ECL intensity. The novel ECL protocol is similar to flow cytometry, but it is no-invasive since extracellular ROS are measured, and has much higher sensitivity because no interference light source is introduced. Clinic applications and practical devices are anticipated. 3. Our hydrophobic and low-cost ILs will be assessed to be electrolytes in Li batteries and electric double layer cells as well as media for electrodeposition of Li electrodes. This will facilitate the fabrication of greener and safer energy storage devices. Our ILs will also be utilized as the main component in membranes of sensitive ion-selective electrodes. All of these research activities will provide excellent opportunities for high quality personnel training, including undergraduate and graduate students. This research will contribute positively to population health, daily life, energy resources and environment in Canada.

这项多学科的建议涉及基于我们在西方建立的研究工具和专业知识的生物学，材料，物理和分析化学。我们打算采用扫描电化学显微镜（SECM），电化学发光（ECL），双极电极（BPE）微流体，共斑拉曼微光谱和离子液体（ILS），以在具有良好应用的新型研究领域：1。Secm的活细胞和肠内材料。 SECM将测量和图像活性氧（ROS），以用于药物分子的细胞功能障碍和刺激。 ROS几乎参与了几乎所有细胞和组织中的生物学活性。我们还将使用SECM来非侵入性地构建许多金属材料的谷物微观结构，例如Zn，Ni电镀式高强度钢，用于制造汽车的热板。我们将将结构与它们的反应性相关联，以进一步提高产品质量与成本比率。预计将在分析仪器和纳米探针制造方面进行进展。 2。ECL微流体。我们将第一次集成一个微流体设备内的BPE，以测量与ECL强度成正比的细胞ROS浓度。新型的ECL方案类似于流式细胞仪，但是由于未引入没有干扰光源，因此它没有侵入性，因此没有侵入性，并且具有更高的灵敏度。预计诊所应用和实用设备。 3。我们的疏水性和低成本IL将被评估为LI电池和电动双层电池中的电解质，以及用于LI电极电沉积的培养基。这将有助于制造绿色和更安全的储能设备。我们的IL还将用作敏感离子选择电极膜中的主要成分。所有这些研究活动将为包括本科和研究生在内的高质量人事培训提供绝佳的机会。这项研究将对加拿大的人口健康，日常生活，能源和环境产生积极贡献。