Understanding host-pathogen interactions between Atlantic salmon and saprolegnia parasitica in order to develop new approaches for disease management

了解大西洋鲑鱼和寄生水霉之间的宿主-病原体相互作用，以开发疾病管理的新方法

• 批准号: 468322-2014
• 负责人: Hintz, William
• 金额: $ 4.59万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=619088
• 关键词: Understanding; host; pathogen; interactions; between

Growth in global fish production is due almost entirely to the increase in fin fish production by aquaculture, representing more than 41% (63.6 million tonnes) of total fish production for human consumption in 2011 (FAO, 2012). The largest cause of economic losses in aquaculture is from fish diseases, with oomycete infections being second only to bacterial infections in terms of their impact. Oomycetes of the genus Saprolegnia can cause saprolegniosis. It is widely recognized by the aquaculture industry in Canada that this disease is prevalent in all freshwater operations and represents an additional cost to fish production due to its impact on fish health. The central scientific objective of this study is to develop experimental tools and generate an information database from which we can attain a better understanding of host-pathogen interactions between the host species of Atlantic salmon and the pathogen Saprolegnia parasitica. An improved understanding of both the infection process and host response will allow us to identify specific elements of each process that may serve as potential gene targets for disease suppression and control. These targets will be examined in subsequent studies focused on control measures for Saprolegniosis. An improved understanding of the infection mechanisms followed by the pathogen, as well as a better understanding of how the host does respond will provide valuable information for disease management by the aquaculture industry.

全球鱼类产量的增长几乎完全是由于水产养殖对鳍鱼产量的增加，占2011年人类消费总生产的41％以上（6360万吨）（粮农组织，2012年）。水产养殖中经济损失的最大原因来自鱼类疾病，卵菌感染仅次于细菌感染。腐生属的卵菌可能会引起腐生。加拿大的水产养殖业广泛认可，这种疾病在所有淡水业务中都普遍存在，并且由于其对鱼类健康的影响而代表了鱼类生产的额外成本。这项研究的核心科学目标是开发实验工具并生成信息数据库，我们可以从中可以更好地了解大西洋鲑鱼与病原体saprolegnia parasitica之间的宿主 - 病原体相互作用。对感染过程和宿主反应的增强理解将使我们能够确定每个过程的特定要素，这些要素可能是抑制疾病和控制的潜在基因靶标。这些目标将在随后的研究中进行检查，该研究的重点是腐生症的控制测量。对感染机制遵循病原体的改进，对宿主的反应方式有了更好的了解，将为水产养殖业提供有价值的信息。