Self-Assembly and Characterization of Block Copolymer Aggregates with a Range of Potential Applications

具有一系列潜在应用的嵌段共聚物聚集体的自组装和表征

• 批准号: RGPIN-2015-06281
• 负责人: Eisenberg, Adi
• 金额: $ 2.04万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=614492
• 关键词: Self; Assembly; Characterization; Block; Copolymer

The work focuses on block copolymer (BC) self-assembly in solution, to yield micelles, rods and especially vesicles, which combine relatively small size with space suitable for loading of both hydrophobic and hydrophilic materials; release profiles will be studied.  Other areas are the formation of nano-particles (NPs), their encapsulation and precise localization within BC aggregates (of interest in catalytic applications). 1) Layer-by-layer (LBL) assembly of various aggregates in sequential multilayers to yield planar nanostructures containing oppositely charged aggregate layers. Large vesicles can also serve as the base structure with surrounding alternating layers of oppositely charged small vesicles and/or micelles to create multilayered nano-capsules resembling blackberries. These structures are of potential interest in catalysis and in the controlled release of multiple ingredients. Thus, one could incorporate different catalytic species into different layers to attempt sequentially catalyzed reactions within a thin layer format. 2) Precise localization of nanoparticles (NPs). Since success has been achieved with symmetric localization of NPs, it is now proposed to explore precise asymmetric localization, e.g. still within a vesicle wall, but closer to one of the interfaces than the other (internal or external). This would be of interest for vesicles in which the exterior and interior interfaces contain different corona chains. Other possibilities include the localization of one type of NP in the hydrophobic center of the vesicle wall or micelle core, with another NP localized at the interior/exterior interface of the vesicle or at the micelle interface. This would be of special interest for for possible use in catalysis. 3) Filling and release of agents from BC aggregates. Multi-component release will be explored from either single systems containing two or more ingredients or from planar or spherical assemblies with the different components in different layers. Interacting components would be of interest under conditions where the combined system has a limited lifetime and the release rate needs to be slow. 4) Morphological control in biocompatible and biodegradable polymers. Release properties from recently prepared lamellar structures will be compared with those from spherical aggregates. Upon successful completion, the proposed research will allow us to design systems capable of controlled release of ingredients from sub-micron size aggregates. If desired it may be possible for those ingredients to undergo catalyzed chemical reactions in the release process under conditions were product degradation on storage may be a problem. Potential applications, with special benefits to Canada, include release (and catalysis) in agricultural or pharmacological settings.

该工作集中于溶液中的块共聚物（BC）自组装，以产生胶束，杆，尤其是囊泡，这些胶囊将相对LL的大小与适合疏水和疏水材料的空间结合在一起；它们在卑诗省的概要区域（催化应用中的意义）中的封装和精确定位。 1）在顺序多层中，逐层（LBL）的均衡器（LBL）均等，以产生平面纳米结构对立面大扇区也可以与带有相对带电的小囊泡/ORLL/ORLL的包围层结构，以创建多层纳米胶囊，这是对催化和催化和催化性和兴趣的潜在兴趣。在受控的铰链ltiple成分中，一个可能的催化层试图尝试依次催化薄层格式。 2）纳米颗粒的精确定位（NP）。囊泡或胶束芯，另一个NP位于囊泡的内部/外部界面或胶束界面上。 3）从包含两种或多种成分的单个系统或在不同层中具有不同组件的单个系统中，将填充和释放bc骨料的释放。组合系统的寿命有限，释放速率需要缓慢。 4）生物相容性和可生物降解聚合物的形态控制。 在成功的情况下，在释放过程中，在释放过程中进行催化的化学反应可能是一个问题，这是一个问题。