Block copolymer self-assembly in solution

嵌段共聚物在溶液中自组装

• 批准号: 4565-2009
• 负责人: Eisenberg, Adi
• 金额: $ 7.65万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=513175
• 关键词: Block; copolymer; self; assembly; solution

Block copolymer vesicles (BCVs) are hollow spheres which can be prepared in solution from amphiphilic diblock copolymers. They range in size from ca. 100 to ca. 1000 nm, with a wall thickness of ca. 20 nm. In early work, we have shown that block copolymer vesicles can be prepared very easily by controlling the preparation conditions. They are part of a morphological continuum which includes spherical micelles and rods. Like liposomes, BCVs are promissing in many potential applications in fields such as pharmacology (in drug delivery), cosmetics and catalysis, but are much more stable than liposomes. We have shown recently that many vesicle parameters, such as size and wall thickness, can be controlled by external preparative conditions and polymer composition. We have also shown that it is possible to prepare, in one step, vesicles with different interior and exterior interfaces. Furthermore, we have shown that it is possible to soften the wall on demand to permit active filling with ingredients such is doxorubicin (a cancer killer), to lock in the ingredients by hardening the wall, and than to "re-open it" on demand to release the contents. We have also shown that it is possible to invert the vesicles by exchanging the interior and exterior interfaces. We now propose to explore a "breathing" mechanism in vesicles which allows them to increase or decrease their volume repeatedly by a factor of ca. 10x within ca. 1 minute. This would allow the uptake and release of ingredients very rapidly. We have also learned how to incorporate nanoparticles such as dendrimers within vesicles walls, and now propose to study systematically the inclusion of a number of different species, including catalysts into vesicle walls. In addition, we propose to examine the incorporation of species of specific geometry (e.g. spheres) into block copolymer aggregates and to study the effect of strong interactions on morphogenesis of the resulting aggregates. Several other minor studies are contemplated including the exploration of diffusion through vesicle walls and the entrapment of large molecules inside the cavities of vesicles.

块共聚物囊泡（BCV）是空心球，可以在两亲性二嵌段共聚物的溶液中制备。它们的大小从CA。 100至CA。 1000 nm，壁厚约为Ca。 20 nm。在早期工作中，我们已经表明，可以通过控制制备条件来轻松制备块共聚物囊泡。它们是形态连续体的一部分，其中包括球形胶束和杆。像脂质体一样，BCV在药理学（药物输送），化妆品和催化等领域的许多潜在应用中都获得了应有的份额，但比脂质体更稳定。我们最近表明，许多囊泡参数，例如大小和壁厚，都可以通过外部制备条件和聚合物组成来控制。我们还表明，可以在一个步骤中准备具有不同内部和外部界面的囊泡。此外，我们已经证明，有可能按需软化墙壁，以允许活跃的成分填充阿霉素（癌症杀手），可以通过硬墙来锁定成分，而不是“重新打开”要求发布内容。我们还表明，可以通过交换内部和外部界面来颠倒囊泡。现在，我们建议在囊泡中探索一种“呼吸”机制，使它们能够反复增加或减少其体积。 CA内的10倍。 1分钟。这将使成分的摄取和释放非常迅速。我们还学会了如何在囊泡壁中纳入纳米颗粒，例如树枝状聚合物，现在建议系统地研究许多不同物种，包括催化剂，包括催化剂到囊泡壁中。此外，我们建议检查特定几何形状（例如球）的掺入块共聚物聚集体中，并研究强相互作用对所得聚集体形态发生的影响。考虑了其他几项次要研究，包括通过囊泡壁扩散的探索以及在囊泡腔内的大分子捕集。