Self-Assembly and Characterization of Block Copolymer Aggregates with a Range of Potential Applications

具有一系列潜在应用的嵌段共聚物聚集体的自组装和表征

• 批准号: RGPIN-2015-06281
• 负责人: Eisenberg, Adi
• 金额: $ 2.04万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=649969
• 关键词: Self; Assembly; Characterization; Block; Copolymer

The work focuses on block copolymer (BC) self-assembly in solution, to yield micelles, rods and especially vesicles, which combine relatively small size with space suitable for loading of both hydrophobic and hydrophilic materials; release profiles will be studied.  Other areas are the formation of nano-particles (NPs), their encapsulation and precise localization within BC aggregates (of interest in catalytic applications). ***1) Layer-by-layer (LBL) assembly of various aggregates in sequential multilayers to yield planar nanostructures containing oppositely charged aggregate layers. Large vesicles can also serve as the base structure with surrounding alternating layers of oppositely charged small vesicles and/or micelles to create multilayered nano-capsules resembling blackberries. These structures are of potential interest in catalysis and in the controlled release of multiple ingredients. Thus, one could incorporate different catalytic species into different layers to attempt sequentially catalyzed reactions within a thin layer format.***2) Precise localization of nanoparticles (NPs). Since success has been achieved with symmetric localization of NPs, it is now proposed to explore precise asymmetric localization, e.g. still within a vesicle wall, but closer to one of the interfaces than the other (internal or external). This would be of interest for vesicles in which the exterior and interior interfaces contain different corona chains. Other possibilities include the localization of one type of NP in the hydrophobic center of the vesicle wall or micelle core, with another NP localized at the interior/exterior interface of the vesicle or at the micelle interface. This would be of special interest for for possible use in catalysis.***3) Filling and release of agents from BC aggregates. Multi-component release will be explored from either single systems containing two or more ingredients or from planar or spherical assemblies with the different components in different layers. Interacting components would be of interest under conditions where the combined system has a limited lifetime and the release rate needs to be slow.***4) Morphological control in biocompatible and biodegradable polymers. Release properties from recently prepared lamellar structures will be compared with those from spherical aggregates. ***Upon successful completion, the proposed research will allow us to design systems capable of controlled release of ingredients from sub-micron size aggregates. If desired it may be possible for those ingredients to undergo catalyzed chemical reactions in the release process under conditions were product degradation on storage may be a problem. Potential applications, with special benefits to Canada, include release (and catalysis) in agricultural or pharmacological settings.**

这项工作的重点是在溶液中自组装嵌段共聚物（BC），以产生胶束、棒，特别是囊泡，它们结合了相对较小的尺寸和适合装载疏水性和亲水性材料的空间；还将研究其他领域。纳米颗粒 (NP) 的形成、它们的封装和在 BC 聚集体中的精确定位（在催化应用中很重要）***1) 逐层 (LBL) 组装。连续多层中的各种聚集体形成包含带相反电荷的聚集体层的平面纳米结构也可以作为基础结构，其周围具有相反电荷的小囊泡和/或胶束的交替层，以产生类似于黑莓的多层纳米胶囊。因此，人们可以将不同的催化物质合并到不同的层中以尝试顺序催化反应。 ***2) 纳米颗粒 (NP) 的精确定位 由于 NP 的对称定位已取得成功，因此现在建议探索精确的不对称定位，例如仍在囊泡壁内，但更接近囊泡壁。一个界面而不是另一个界面（内部或外部）这对于外部和内部界面包含不同冠链的囊泡来说是有意义的。 NP 位于囊泡壁或胶束核心的疏水中心，另一个 NP 位于囊泡的内/外界面或胶束界面，这对于可能用于催化可能具有特殊意义。***3) BC 聚集体中药剂的填充和释放将通过包含两种或多种成分的单一系统或不同层中具有不同成分的平面或球形组件来探索。在组合系统的寿命有限且释放速率需要较慢的情况下，这将是令人感兴趣的。***4) 生物相容性和可生物降解聚合物的形态控制将与最近制备的层状结构的释放特性进行比较。 ***成功完成后，拟议的研究将使我们能够设计能够从亚微米尺寸的聚集体中控制释放成分的系统，如果需要，这些成分可能会在释放过程中发生催化化学反应。条件是产品储存降解可能是一个问题，对加拿大有特殊好处，包括在农业或药理学环境中的释放（和催化）。**