Development of Functional Peptide Nanostructures

功能性肽纳米结构的开发

• 批准号: 197473-2012
• 负责人: Voyer, Normand
• 金额: $ 4.01万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593737
• 关键词: Development; Functional; Peptide; Nanostructures

Inspired by the properties of natural proteins, our group is working to construct artificial molecular systems of nanometer dimension designed to perform specific tasks with unprecedented level of efficiency. Even though great successes have been achieved using creative approaches, lot more work is necessary to delineate the molecular guidelines to predict and understand the functions of artificial nanoscale systems and, most importantly, to exploit them into routine practical applications. The unifying theme of our program is the construction of unique nanoscale molecular architectures with tailor-made functions exploiting the power of combining chemical synthesis with the advantages of peptidic structures. More specifically, this proposal describes three research areas where we will invest our efforts; 1) the use of artificial ion channels for the development of real-time sensing devices for biologically relevant analytes, 2) the development of selective nanochemotherapeutics, and 3) the discovery of efficient antimicrobials based on crown peptide nanostructures.

受天然蛋白质的特性的启发，我们的小组正在努力构建纳米尺寸的人工分子系统，旨在执行以前所未有的效率水平执行特定任务。尽管使用创造性的方法取得了巨大的成功，但要描述分子准则，以预测和理解人造纳米级系统的功能，最重要的是，将它们利用为常规的实用应用是必要的。我们程序的统一主题是构建具有量身定制功能的独特纳米级分子体系结构，从而利用化学合成与肽结构的优势相结合的功能。更具体地说，该提案描述了三个研究领域，我们将投入我们的努力。 1）使用人工离子通道来开发用于生物学相关分析物的实时传感设备，2）选择性纳米化学疗法的开发，以及3）发现基于冠状肽纳米结构的有效抗菌剂的发现。