Non-canonical Wnt signaling and lymphostromal interactions: the role of Wnt4/Frizzled6 axis in early immune development

非经典 Wnt 信号传导和淋巴间质相互作用：Wnt4/Frizzled6 轴在早期免疫发育中的作用

• 批准号: 419226-2012
• 负责人: Heinonen, Krista
• 金额: $ 2.4万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=551606
• 关键词: Non; canonical; Wnt; signaling; lymphostromal

All cells of the adult immune system are derived from a small number of bone marrow hematopoietic stem cells (HSC) that are found in specialized pockets or niches, surrounded by other cells that are believed to regulate HSC function. In addition to being able to develop into the different blood cell lineages, HSC also have the unique ability to self-renew. Their infrequent cell divisions are asymmetrical, resulting in the generation of one daughter HSC, identical to the mother cell, and one progenitor cell that has lost several stem cell characteristics. This self-renewal is dependent on HSC-niche interactions and is essential for the continuous generation of circulating blood cells. One of the greatest technical challenges in the field is to develop methods for HSC expansion in culture while limiting the loss of their self-renewal capacity.

成人免疫系统的所有细胞均来自少数骨髓造血干细胞（HSC），这些干细胞（HSC）被发现在专门的口袋或壁ches中，被认为可以调节HSC功能的其他细胞包围。除了能够发展为不同的血细胞谱系外，HSC还具有独特的自我更新能力。它们的细胞分裂不对称是不对称的，导致一个女儿HSC产生与母细胞相同的女儿HSC，并且一个遗传了几个干细胞特征的祖细胞。这种自我更新取决于HSC-niche相互作用，对于连续产生循环血细胞至关重要。该领域最大的技术挑战之一是开发文化中HSC扩展的方法，同时限制其自我更新能力的丧失。