Soft Biomolecular Materials and Interfaces

软生物分子材料和界面

基本信息

批准号：
327200-2012
负责人：
Harden, James
金额：
$ 4.44万
依托单位：
University of Ottawa
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2014
资助国家：
加拿大
起止时间：
2014-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549004
关键词：
Soft Biomolecular Materials Interfaces

项目摘要

This proposed research program combines elements of protein design, biophysics, and soft condensed matter physics to create and study novel protein-based soft nanostructured materials based on biomolecular self-assembly. My lab has expertise in the use of established biological methods for creating polymer-like proteins with novel structural and functional features. One of the outstanding advantages of biologically engineered protein polymers is the ability to precisely control their sequence and molecular weight, thereby allowing for the selection of molecular attributes (such as protein conformation) and control of the association of proteins into supramolecular assemblies and materials. Such protein-based materials have a wide variety of applications in cell and tissue engineering, regenerative medicine and targeted drug delivery. The proposed program will focus on several thematic areas: (1) Associating protein networks, (2) Soft Biofunctional Protein Interfaces, and (3) Soft Protein-Inorganic Nanocomposite Materials. The research in these interdisciplinary thematic areas will build on my current research programs and existing collaborative relationships with groups in Canada and abroad, and will provide HQP with a broad and cutting edge training experience that will prepare them for careers in this rapidly developing interdisciplinary biomaterials field.

该提出的研究计划结合了蛋白质设计，生物物理学和软凝分物理学的元素，以创建和研究基于生物分子自组装的新型基于蛋白质的软纳米结构材料。我的实验室在使用已建立的生物学方法方面具有专业知识来创建具有新型结构和功能特征的聚合物样蛋白。生物工程蛋白聚合物的出色优势之一是能够精确控制其序列和分子量的能力，从而可以选择分子属性（例如蛋白质构象）以及控制蛋白质与蛋白质与超分子组件和材料的缔合的能力。这种基于蛋白质的材料在细胞和组织工程，再生医学和靶向药物递送中具有多种应用。提出的程序将重点放在几个主题领域：（1）蛋白质网络，（2）软蛋白质蛋白接口和（3）软蛋白质无机纳米复合材料。这些跨学科主题领域的研究将建立在我当前的研究计划以及与加拿大和国外团体的现有协作关系的基础上，并将为HQP提供广泛而尖端的培训经验，这将使他们在这个迅速发展的跨学科生物材料领域的职业生涯做好准备。