Anti-microbial scaffold materials for cutaneous wound healing

用于皮肤伤口愈合的抗菌支架材料

• 批准号: 414290-2012
• 负责人: Harden, James
• 金额: $ 7.19万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=530864
• 关键词: Anti; microbial; scaffold; materials; cutaneous

This proposed research is focused on the development of new functional biomaterials for the repair of chronic degradation and infection of skin. Loss of nerves and sensitivity occur in the skin of extremities in chronic type II diabetes, often resulting in epithelial erosion and ulceration. In addition to the loss of sensitivity, the chronic ulceration renders the skin prone to bacterial infection that can lead to gangrene and amputations. In addition, although skin and skin substitutes have been around for a long time for use in burn patients, there are still issues with scarring, especially for deeper skin wounds that involve the dermis and sub-cutaneous fat tissue. Successful strategies for such reconstruction of skin depend crucially on the availability of scaffold materials that (1) recapitulate the native extracellular matrix (ECM) environment (a largely collagenous matrix with

这项拟议的研究重点是开发用于修复皮肤慢性退化和感染的新型功能性生物材料。慢性II型糖尿病患者的四肢皮肤会出现神经和敏感性丧失，常常导致上皮糜烂和溃疡。除了失去敏感性之外，慢性溃疡还使皮肤容易受到细菌感染，从而导致坏疽和截肢。此外，尽管皮肤和皮肤替代品长期以来一直用于烧伤患者，但仍然存在疤痕问题，特别是涉及真皮和皮下脂肪组织的较深皮肤伤口。这种皮肤重建的成功策略在很大程度上取决于支架材料的可用性，这些材料（1）概括了天然细胞外基质（ECM）环境（主要是胶原蛋白基质，