Signal and image processing methods for studying human ventricular fibrillation

研究人体心室颤动的信号和图像处理方法

• 批准号: 386738-2010
• 负责人: Umapathy, Karthikeyan
• 金额: $ 2.04万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=509615
• 关键词: Signal; image; processing; methods; studying

The heart is a versatile electro-mechanical organ that is driven by autonomously generated rhythmic electrical pulses within it. When the electrical generation or conduction system of the heart malfunctions or is diseased, the heart quivers with arrhythmic and chaotic contractions, resulting in ineffective or cessation of blood circulation to vital organs. This medical condition in general is termed as cardiac arrhythmia. When this happens in the ventricles (lower chambers of the heart responsible for pushing out blood), a serious medical condition called ventricular fibrillation (VF) occurs. VF, if untreated within minutes of its occurrence, leads to sudden cardiac death (SCD). Every year in North America about 350,000 SCDs (with 45,000 of them in Canada, i.e. an SCD every 12 minutes) are reported, most of which are VF related. In spite of its importance, and active research over 100 years, the mechanism behind human VF is still elusive because of the non-stationary nature of the process and ethical/practical limitations in studying human VF.

心脏是一种多功能机电器官，由内部自主产生的有节奏的电脉冲驱动。当心脏的发电或传导系统出现故障或患病时，心脏会因心律失常和混乱的收缩而颤动，导致重要器官的血液循环无效或停止。这种医疗状况通常被称为心律失常。当这种情况发生在心室（心脏的下腔室，负责排出血液）时，就会出现一种称为心室颤动 (VF) 的严重疾病。心室颤动如果在发生后几分钟内未得到治疗，会导致心源性猝死 (SCD)。北美每年报告约 350,000 起 SCD（其中加拿大有 45,000 起，即每 12 分钟发生一次 SCD），其中大多数与室颤相关。尽管人类心室颤动很重要，并且研究已经持续了 100 多年，但由于过程的非平稳性以及研究人类心室颤动的伦理/实践限制，人类心室颤动背后的机制仍然难以捉摸。