A framework for the in silico modeling and investigation of time dependent photobiophysical phenomena

时间依赖性光生物物理现象的计算机建模和研究框架

• 批准号: 238337-2010
• 负责人: Baranoski, Gladimir
• 金额: $ 1.46万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=508055
• 关键词: framework; silico; modeling; investigation; time

The predictive assessment of the beneficial and harmful effects of light (radiation) incidence on plant and human tissues, from photosynthesis to the development of cancer, is of fundamental importance since it can be used to improve the quality of human and animal life and to provide alternatives for environmental problems on a global scale. The purpose of this research program is to break new ground toward such an assessment. It will expand the boundaries of realistic image synthesis through the predictive simulation of time dependent photobiophysical phenomena responsible for appearance changes in natural materials. Skin related processes, such as tanning, aging and lesion formation, triggered by ultraviolet radiation are examples of such phenomena. In these cases, the simulation of appearance changes may be used to assist the prevention, diagnosis and treatment of skin diseases. Color changes observed in plant leaves under nutrient and water stress are also examples of such phenomena. In these cases, "virtual" experiments can provide reliable feedback with respect to different agricultural strategies that can be applied to cope with these adverse conditions and improve crop production. Once a computer simulation framework is designed and validated through a sound scientific methodology, as proposed in this research program, it can be employed in the "in silico" investigation of phenomena that cannot be fully studied through traditional experimental procedures. Accordingly, it can be used to assist in the hypothesis generation and validation cycles of research in different scientific domains. Hence, the proposed simulation framework will contribute to interdisciplinary research efforts in fields such as biomedical optics, biophysical dermatology and remote sensing, in addition to fundamental contributions to computer graphics through the design of predictive algorithms for the generation of realistic images depicting time dependent appearance changes, Furthermore, this research program may lead to the emergence of innovative technologies (e.g., new devices for the noninvasive diagnostic of medical conditions) as well as the establishment of government policies for ecological issues and testing protocols for new protective materials.

从光合作用到癌症发展的光（辐射）发病率对植物和人体组织的有益和有害影响的预测评估至关重要，因为它可用于改善人类和动物生活的质量，并在全球规模上为环境问题提供替代方案。该研究计划的目的是为了进行这种评估而开展新的基础。它将通过预测依赖的光生物物理现象的预测模拟造成天然材料外观变化的时间来扩大现实图像合成的边界。由紫外线辐射触发的皮肤相关的过程，例如晒黑，衰老和病变形成，就是这种现象的例子。 在这些情况下，外观变化的模拟可用于帮助预防，诊断和治疗皮肤病。在养分下观察到的植物叶子观察到的颜色变化也是这种现象的例子。在这些情况下，“虚拟”实验可以提供有关不同农业策略的可靠反馈，这些策略可用于应对这些不利条件并改善作物的产量。在本研究计划中提出的那样，一旦计算机模拟框架通过合理的科学方法设计和验证，就可以在对现象的“计算机”调查中使用，该研究无法通过传统的实验程序进行全面研究。因此，它可用于协助不同科学领域的研究的假设产生和验证周期。因此，提出的仿真框架将在生物医学光学，生物物理皮肤病学和遥感等领域的跨学科研究工作，除了通过设计预测算法的基本贡献，除了对计算机图形的基本贡献外，还可以设计出依赖时间的开发计划，以实现依赖于时间的启示，该技术的新技术可能会导致该技术的出现。医疗状况的无创诊断）以及为新保护材料制定生态问题和测试方案的政府政策。