Optimization of growth conditions of the microalga Oocystis polymorpha in photo-bioreactors for the production of carotenoids targeted for use as antioxidants for nutraceutical pur

优化光生物反应器中微藻卵囊菌的生长条件，用于生产类胡萝卜素，该类胡萝卜素用作营养保健品的抗氧化剂

• 批准号: 417879-2011
• 负责人: Popovic, Radovan
• 金额: $ 1.82万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=494825
• 关键词: Optimization; growth; conditions; microalga; Oocystis

Some microalgae are particularly interesting because of their efficiency to produce antioxidant carotenoids, including astaxanthin, which have been proved to benefit human and animal health and nutrition. The aim of this project is to develop growth conditions for the microalga Oocystis polymorpha in order to produce maximal astaxanthin, combining it with the expertise of algae growing in photo-bioreactors from NutrOcean Company and adapting to this species. The eventual aim of the company is to produce astaxanthin from microalgae, using it in the nutraceutical field. A stepwise scaling-up will be carried out to eventually produce up to 2 L of the culture in a bioreactor. Different conditions will be optimized in order to achieve the highest mass algal production with a maximal carotenoid accumulation. NutrOcean is a marine farming production company located in Rimouski, specialized in the development and commercialization of microalgal products. NutrOcean has currently looking to penetrate the nutraceutical market, more specifically using omega 3 and astaxanthin in dietary supplements and functional food. Astaxanthin supplements have been available to the public for quite a number of years. However, the most commercially available form of this carotenoid is from synthetic sources. Today, there is a need to find alternate ways of producing natural astaxanthin. Since one of the major missions of NutrOcean is to capture the nutraceutical astaxanthin market the company is interested for technologies producing carotenoids from microalgae. The know-how of Dr. Popovic's team therefore, directly fits the need of the company at solving the company-specific problem through the application of existing knowledge in an innovative manner. Therefore, this contribution on technology transfer will allow a Canadian company to be in a leading position in the nutraceutical field. Such biotechnology oriented to obtain from microalgae specific carotenoids with high antioxidant properties presently does not exist in Canada.

一些微藻特别令人感兴趣，因为它们能够有效产生抗氧化剂类胡萝卜素，包括虾青素，已被证明有益于人类和动物的健康和营养。该项目的目的是开发微藻 Oocystis polymorpha 的生长条件，以生产最大量的虾青素，并将其与 NutrOcean 公司光生物反应器中藻类生长的专业知识相结合并适应该物种。该公司的最终目标是从微藻中生产虾青素，并将其用于营养保健品领域。将逐步扩大规模，最终在生物反应器中生产多达 2 L 的培养物。将优化不同的条件，以实现最大量的藻类生产和最大的类胡萝卜素积累。 NutrOcean 是一家位于里穆斯基的海洋养殖生产公司，专门从事微藻产品的开发和商业化。 NutrOcean 目前正寻求打入营养保健品市场，更具体地说，是在膳食补充剂和功能性食品中使用 omega 3 和虾青素。虾青素补充剂已经向公众提供很多年了。然而，这种类胡萝卜素最商业化的形式是合成来源。如今，需要寻找生产天然虾青素的替代方法。由于 NutrOcean 的主要使命之一是占领营养虾青素市场，该公司对从微藻中生产类胡萝卜素的技术很感兴趣。因此，Popovic 博士团队的专业知识直接满足公司通过以创新方式应用现有知识来解决公司特定问题的需求。因此，这项技术转让的贡献将使加拿大公司在营养保健品领域处于领先地位。目前加拿大尚不存在这种旨在从微藻中获取具有高抗氧化特性的特定类胡萝卜素的生物技术。