Space Optimization, Allergen Mitigation, and Improved Microenvironmental Conditions in a Shared Use Animal Facility at Florida State University

佛罗里达州立大学共享动物设施的空间优化、过敏原缓解和改善微环境条件

• 批准号: 10735627
• 负责人: William Allen Hill
• 金额: $ 34.93万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10735627
• 关键词: Agriculture; Air; Allergens; Ammonia; Animal Welfare; Animals; Area; Biological Sciences; Biomedical Research; Carbon Dioxide; Data Science; Engineering; Enrollment; Ensure; Environment; Exposure to; Faculty; Florida; Funding; Future; Goals; Growth; Health Personnel; Human Resources; Humidity; Immunocompromised Host; Individual; Infrastructure; Investigation; Laboratory Animals; Location; Mechanics; Medical Research; Medical Students; Mentors; Modernization; Modification; Monitor; Mus; Occupational; Occupational Health; Oxygen; Positioning Attribute; Publishing; Rattus; Request for Proposals; Research; Research Personnel; Risk; Rodent; Safety; Sampling; Side; System; Technology; Temperature; Translating; United States National Institutes of Health; Universities; Work; air sampling; animal care; animal facility; animal resource; effectiveness evaluation; effectiveness testing; experience; health data; improved; innovation; programs; research facility; success; tenure track; ventilation

PROJECT SUMMARY This proposal requests funds to acquire Tecniplast Emerald EM500 individually ventilated caging (IVC) systems to modernize and incorporate the latest IVC technology into a shared use vivarium at Florida State University (FSU). The FSU Animal Care and Use Program is poised to experience unprecedented growth as a result of the University President’s bold and ambitious agenda to increase annual research funding from $328M to $500M by building capacity in life sciences, medical research, and health data sciences and by hiring approximately 170 new, full- time, tenure-track faculty. The open-top and microisolator caging used program-wide cannot support the anticipated growth within existing facilities. Moreover, the expansion of the FSU research enterprise will undoubtedly translate into an increase in work with immunocompromised rodents and hazardous agents, which due to the lack of appropriate engineering controls, the University is presently ill-equipped to handle. Additionally, recent consultancy studies commissioned by the FSU Office of the Vice President for Research (OVPR) have identified occupational health concerns, specifically personnel exposure to laboratory animal allergens associated with the widespread use of open-top caging. The goal of this project is to acquire six single-sided mouse racks, three double-sided mouse racks, and one single-sided rat rack for the Biomedical Research Facility (BRF) vivarium, which, in combination, will provide 1,092 cage spaces for rodents and increase the mouse cage holding capacity of the vivarium by 162%. In addition to space optimization, the IVC technology requested is expected to mitigate occupational allergen exposure risks, provide appropriate engineering controls for work with immunocompromised rodents and hazardous agents, and improve microenvironmental conditions for FSU animal resources. The operational innovation and benefits to personnel health and safety and animal welfare achieved by the success of this proposal will uniquely position FSU and LAR to meet the demands of a burgeoning research enterprise and the needs of current and future NIH-funded investigators.

项目摘要 该提案要求资金以单独通风获得Tecniplast Emerald EM500 笼（IVC）系统，将最新的IVC技术现代化并将其纳入共享用途 佛罗里达州立大学（FSU）的Vivarium。 FSU动物护理和使用程序中毒 由于大学校长大胆而雄心勃勃 Agernda通过建立生活能力将年度研究资金从3.28亿美元增加到5亿美元 科学，医学研究和健康数据科学，以及雇用大约170个新的，全面的 时间，终身教师。开放式和微极性笼中使用的程序范围无法 支持现有设施内的预期增长。而且，FSU的扩展 研究企业无疑将转化为工作的增加 免疫功能低下的啮齿动物和危险剂，由于缺乏适当的 该大学的工程控制措施是为处理不足的。另外，最近 咨询研究由FSU研究副总裁委托 （OVPR）已经确定了职业健康问题，特别是人员接触 实验室动物过敏原与开放式笼的宽度使用相关。目标 该项目是获取六个单面鼠标架，三个双面鼠标架，一个 生物医学研究设施（BRF）Vivarium的单侧大鼠架 将为啮齿动物提供1,092个笼子空间，并增加小鼠笼子的握持能力 Vivarium增长162％。除了空间优化外，还需要提出的IVC技术 为了减轻职业过敏原暴露风险，提供适当的工程控制 与免疫功能低下的啮齿动物和危险剂一起工作，并改善 FSU动物资源的微环境条件。运营创新和 通过成功的成功对人事健康和安全和动物福利的好处 提案将独特地定位FSU和LAR，以满足水爆研究的需求 企业以及当前和未来的NIH资助的研究人员的需求。