Understanding the physiological consequences of biased signalling mediated by the glucagon-like peptide-1 receptor

了解胰高血糖素样肽 1 受体介导的偏向信号的生理后果

• 批准号: nhmrc : 1065410
• 金额: $ 42.44万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-physiological-consequences-1-receptor/455168
• 关键词: Understanding; physiological; consequences; biased; signalling

The glucagon-like peptide 1 receptor is a major target for treatment of Type 2 diabetes and obesity. However, the development of drugs targeting this receptor is challenging as activation by different ligands can result in distinct signalling biases, a paradigm for which there is limited understanding of the physiological consequences. This project will address this critical knowledge gap and may allow for development of novel drugs with improved therapeutic outcomes.

胰高血糖素样肽 1 受体是治疗 2 型糖尿病和肥胖症的主要靶点。然而，针对该受体的药物开发具有挑战性，因为不同配体的激活可能会导致不同的信号传导偏差，而对这种范例的生理后果了解有限。该项目将解决这一关键的知识差距，并可能有助于开发具有改善治疗效果的新药。